Informet XR 750 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (1 x 30: ৳ 270.00)
Strip Price: ৳ 270.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Used as monotherapy or in combination with other oral antidiabetic agents or with insulin
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
Dosage & Administration
- Dosage individualized based on effectiveness and tolerance
- Usual starting dose for adults: 500mg-850mg per day
- Usual starting dose for children: 500mg per day
- Dosage increases should be made in specific increments
- Do not exceed maximum recommended daily doses
Interaction
- Potential interaction with Furosemide and Nifedipine
- Effect on cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia may interact with Informet XR
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis or severe renal failure
- Conditions that may alter renal function or cause tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Metformin excreted into human breast milk
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of lactic acidosis increases with impaired renal function
- Lower vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin
- Regular monitoring of renal function advised
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly subjects
- Confirmation of type 2 diabetes mellitus before treatment initiation in children
- Regular assessment of renal function necessary in all diabetics
Overdose Effects
- Hypoglycemia has not been seen with Informet XR doses up to 85 gm
- Lactic acidosis is a medical emergency and must be treated in hospital
- Hemodialysis is the most effective method to remove lactate and Informet XR
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children