DMF 850 mg (Tablet)

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Doctor tims pharmaceuticals ltd
Also available as
Dmf 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Monotherapy in adults
  • Combination therapy in adults
  • Combination therapy in children and adolescents
  • Reduction of diabetic complications in overweight patients

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • No production of hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity
  • Increases peripheral glucose uptake and utilization

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Different dosage for immediate release and extended release tablets
  • Dosage adjustments for adults and children
  • Special instructions for renal impaired patients

Interaction

  • Interaction with Furosemide
  • Enhancement of absorption by Nifedipine
  • Potential interaction with cationic drugs
  • Effect on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy
  • Increased risk of congenital abnormalities and perinatal mortality
  • Excretion into human breast milk
  • No adverse effects observed in breastfed newborns/infants

Precautions & Warnings

  • Excretion by the kidney
  • Risk of DMF accumulation and lactic acidosis
  • Lowering of vitamin B12 level
  • Risk of hypoglycemia in combination with insulin
  • Regular monitoring of renal function
  • Surgery and clinical investigation precautions
  • Diabetes stabilization precautions
  • Renal clearance during cimetidine therapy
  • Interaction with anticoagulants

Use in Special Populations

  • Elderly dosage adjustments
  • Effect on growth and puberty
  • Recommendations for prepubescent children
  • Importance of assessing renal function
  • Caution in situations of impaired renal function
  • Contradictions with low GFR

Overdose Effects

  • No hypoglycemia seen with DMF doses up to 85 gm
  • Occurrence of lactic acidosis
  • Hemodialysis for treatment

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature and light/moisture protection
  • Keep out of the reach of children

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