E-Proton 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (10 x 10: ৳ 700.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Doctor tims pharmaceuticals ltd
Also available as
E proton 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms and GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of H+/K+-ATPase
  • Enteric-coated pellet formulation
  • Peak plasma levels at 1.5 hours
  • Metabolized in the liver by CYP enzymes
  • Plasma protein binding is 97%
  • Approximately 1-1.5 hours elimination half-life

Dosage

  • 20 mg or 40 mg Once Daily for Healing of Erosive Esophagitis
  • 20 mg Once Daily for Maintenance of Healing
  • 20 mg Once Daily for Symptomatic GERD
  • 40 mg Once Daily for Helicobacter Pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome

Administration

  • Tablet or capsule should be swallowed whole
  • Oral Suspension should be taken with water
  • IV Injection or IV infusion for specific conditions

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • No significant interactions with certain CYP enzymes
  • Potential interference with CYP2C19 and gastric pH dependent drugs
  • No changes noted with oral contraceptives, diazepam, phenytoin, or quinidine

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate studies in pregnant women
  • No teratogenic effects reported in animals
  • Breastfeeding not recommended

Precautions & Warnings

  • Symptomatic response does not rule out gastric malignancy
  • Instructions for patients on capsule administration
  • Use of antacids with caution

Use in Special Populations

  • Safety not established in paediatric patients
  • No significant differences between elderly and younger individuals
  • No dosage adjustment for mild to moderate hepatic insufficiency

Overdose Effects

  • Lethal dose in rats reported
  • Major signs of acute toxicity include reduced motor activity, tremor, convulsions
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about E-Proton 20 mg Capsule

  • Uses of E-Proton 20 mg Capsule
  • Side effects of E-Proton 20 mg Capsule
  • Pregnancy and breastfeeding considerations
  • Time taken for E-Proton 20 mg Capsule to work
  • Quick tips for taking E-Proton 20 mg Capsule

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