Semaglo 7 mg (Tablet)
Unit Price: ৳ 750.00 (1 x 10: ৳ 7,500.00)
Strip Price: ৳ 7,500.00
Medicine Details
Indications
- Adjunct to diet and exercise for type 2 diabetes mellitus
- Reduction of major adverse cardiovascular events in type 2 diabetes mellitus with established cardiovascular disease
- Chronic weight management in adults with obesity or overweight
Mode of Action
Acts as a GLP-1 receptor agonist to stimulate insulin secretion, lower glucagon secretion, and reduce body weight by reducing appetite.
Dosage & Administration
- Starter dose of 3mg once daily, maintenance dose of 7mg, can be increased to 14mg for additional glycemic control
- Injection starting dose of 0.25mg once weekly, can be increased to 1mg once weekly
- Dosing for obesity starting from 0.25mg once weekly, with dose escalation and maintenance dose
Interaction
Can impact the rate of absorption of concomitantly administered oral medicinal products
Contraindications
Hypersensitivity to the active substance or excipients
Side Effects
- Hypoglycemia when used with insulin or sulfonylurea
- Gastrointestinal disorders, nausea, diarrhea, vomiting, abdominal pain, constipation
- Allergic reaction, injection site reaction, lipodystrophy, pruritus, rash
Pregnancy & Lactation
Not to be used during pregnancy or breastfeeding
Precautions & Warnings
- Not for use in type 1 diabetes mellitus or diabetic ketoacidosis
- Discontinue if pancreatitis is suspected, caution for patients with diabetic retinopathy
- Monitoring needed for pediatric population, elderly, renal impairment, and hepatic impairment
Use in Special Populations
- Safety and efficacy in children and adolescents not yet established
- No dose adjustment required for elderly, mild to severe renal impairment, or hepatic impairment. Not recommended for end-stage renal disease
Overdose Effects
- Reported overdose effects of nausea
- No specific antidote, appropriate supportive treatment needed
- Dose adjustment for existing therapy of metformin and/or thiazolidinedione, sulfonylurea, or insulin
- Guidelines for missed dose administration
Therapeutic Class
GLP-1 receptor agonists
Storage Conditions
Store at 2°C to 8°C, do not freeze, keep out of reach of children
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