I-POP 10 mg (Tablet)

Product Title

• I-POP 10 mg Tablet

Categories

• Medicine
• Pharmaceutical

Description

• Dopamine antagonist medication for the treatment of nausea and vomiting.
• Pharmacological actions include blocking dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach, restoring normal motility and tone of the upper gastrointestinal tract, facilitating gastric emptying, and enhancing antral and duodenal peristalsis.

Dosage & Administration

• Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily
• Maximum dose: 80 mg daily
• Children: Dosage based on body weight and specific conditions

Interaction

• Concomitant administration of anticholinergic drugs may antagonize the antidyspeptic effect of domperidone
• Avoid simultaneous use with antacids and antisecretory drugs
• Metabolized through CYP3A4 pathway
• May influence the absorption of concomitantly orally administered drugs

Contraindications

• Hypersensitivity to the drug
• Neonates
• Gastrointestinal hemorrhage, mechanical obstruction, or perforation
• Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

• Rare side effects include transient intestinal cramps
• Extrapyramidal phenomena are rare in young children and adults
• Potential increase in plasma prolactin level

Pregnancy & Lactation

• Use during first trimester if justified by therapeutic benefit
• Excreted in breast milk, caution advised for nursing mothers

Precautions & Warnings

• Caution in children due to risk of extra-pyramidal reactions
• Use with caution in patients with hepatic impairment

Use in Special Populations

• Use in infants under close medical supervision due to incomplete development of blood-brain barrier
• Caution advised in patients with hepatic or renal impairment

Overdose Effects

• Symptoms include drowsiness, disorientation, and extrapyramidal reactions

Therapeutic Class

• Motility Stimulants
• Dopamine antagonist
• Prokinetic drugs

Storage Conditions

• Store below 30°C, protected from light & moisture

Chemical Structure

• Molecular Formula: C22H24ClN5O2

Common Questions & Answers

• I-POP 10 mg Tablet is used to treat nausea and vomiting
• Quick tips for usage, including precautions and side effects

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