Ketofenac 10 mg (Tablet)

Unit Price: ৳ 10.00 (2 x 10: ৳ 200.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Doctor tims pharmaceuticals ltd
Also available as
Ketofenac 30 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Biological activity associated with the S-form
  • Highly protein-bound
  • Metabolized in the liver
  • Metabolites and some unchanged drugs are excreted in urine

Pharmacology

  • Potent analgesic
  • Inhibits the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at its analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours, short-term use only
  • Injection: Used for the management of moderately severe, acute pain
  • Analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours
  • Different dosing for different age groups and conditions
  • Eye Drops: 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin: Increase the side effects
  • Anti-coagulants: Enhance anti-coagulant effect
  • Beta Blocker: Reduce the anti-hypertensive effect
  • ACE Inhibitors: Increase the risk of renal impairment
  • Methotrexate: Enhance the toxicity of methotrexate

Contraindications

  • Hypersensitivity to the drug or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melana
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions & Warnings

  • Caution in patients over the age of 65 years
  • Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding, asthma, and liver dysfunction
  • Eye Drops: Discontinue if corneal epithelial breakdown is present, avoid use with contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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