Losark 50 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Doctor tims pharmaceuticals ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binding to the AT1 receptor in various tissues
- Reduction of vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily recommended if 50 mg is inadequate
- Lower starting dose of 25 mg for patients over 75 years
- Total daily dose ranges from 25 mg to 100 mg
Interaction
- Reduction of active metabolite levels by Rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increase in serum potassium with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
Contraindications
- Pregnancy
- Hypersensitivity to any component of the product
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects: dizziness, diarrhea, nasal congestion, cough
- Other side effects: fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus during second or third trimester
- Potential excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Consideration of lower dose for patients with hepatic impairment
- Contraindicated in pregnancy and patients hypersensitive to losartan
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children