Metfolin 2.5 mg+500 mg (Tablet)
Unit Price: ৳ 12.00 (2 x 10: ৳ 240.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Doctor tims pharmaceuticals ltd |
Indications
- Improving glycemic control in adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
Pharmacology
- Inhibitor of DPP-4 enzyme
- Increases active incretin hormones
- Stimulates insulin release from pancreatic beta cells
- Decreases glucagon secretion from pancreatic alpha cells
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Dose escalation should be gradual
- Recommended starting dose for patients not treated with Metformin Hydrochloride
- Individualized dosage based on effectiveness and tolerability
Interaction
- Potential interaction with cationic drugs
- Risk of metabolic acidosis with carbonic anhydrase inhibitors
- Effects of rifampin on Linagliptin exposure
- Impact of certain drugs on glycemic control
Contraindications
- Contradicted in patients with renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common side effects: nasopharyngitis and diarrhea
- Hypoglycemia more common in patients treated with Metformin and sulfonylureas
Pregnancy & Lactation
- Should be used during pregnancy only if clearly needed
- Caution in administration to lactating mothers
Precautions & Warnings
- Discontinue in case of lactic acidosis or suspected pancreatitis
- Monitoring of Vitamin B12 levels
- Instructions for alcohol consumption
- Precautions for travel and emergencies
Overdose Effects
- Usual supportive measures in the event of overdose
- Dialyzable nature of Metformin Hydrochloride
- No dose-related clinical adverse drug reactions with Linagliptin
- Hypoglycemia and lactic acidosis reported in Metformin Hydrochloride overdose cases
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children
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