Nok 15 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Midazolam |
| Company | Doctor tims pharmaceuticals ltd |
| Also available as |
Title
Nok Sleep-Inducing Agent
Categories
- Medicine
- Sleep Aid
- Sedative
- Hypnotic
- Anxiolytic
Description
Nok is a sleep-inducing agent characterized by a rapid onset and short duration of action. It also exerts an anxiolytic, anticonvulsant and muscle-relaxant effect.
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Mode of Action
Benzodiazepines such as Midazolam increase the activity of GABA, producing a sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia.
Dosage & Administration
- Oral Dosage:
- For adults: 7.5-15 mg daily
- In elderly and debilitated patients: 7.5 mg
- In premedication: 15 mg of Midazolam should be given 30-60 minutes before the procedure
- Intravenous Administration:
- Endoscopic or Cardiovascular Procedures: In healthy adults, the initial dose is approximately 2.5 mg
- Induction of Anesthesia: 10-15 mg
- Intramuscular Administration:
- Adult: 0.07-0.1 mg/kg body weight
- Children: 0.15-0.20 mg/kg
- Elderly and debilitated patients: 0.025-0.05 mg/kg
- Rectal Administration in Children: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min. before induction of general anesthesia
Interaction
Nok can enhance the central sedative effect of various drugs including neuroleptics, tranquillizers, antidepressants, and more.
Contraindications
Must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, and with known hypersensitivity to benzodiazepines.
Side Effects
May include drowsiness, confusion, fatigue, headache, muscle weakness, respiratory depression, apnea, variations in blood pressure and pulse rate.
Pregnancy & Lactation
Should be avoided during pregnancy unless there is no safer alternative. It should not be administered to breast-feeding mothers.
Precautions & Warnings
Nok IV should be administered very slowly.
Overdose Effects
Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression, and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil.
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
Protect from light and moisture, store in a cool and dry place. Keep out of the reach of children.
Color Options
- White
- Blue
Packaging Options
- Bottles
- Blister Packs
Usability Features
- Rapid onset of action
- Short duration of action
Technical Specifications
- GABA receptor modulator
- Anxiolytic effect
- Anticonvulsant effect
Design Elements
- Easy-to-open packaging
- Clear dosage instructions
Materials
- Active ingredient: Midazolam
- Inactive ingredients: Excipients
Dimensions
Standard packaging sizes