Efirel 10 mg (Tablet)

Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Prasugrel hydrochloride
Company Opsonin pharma ltd
Also available as

Therapeutic Class

  • Anti-platelet drugs

Indications

  • Reduction of thrombotic cardiovascular events
  • Management of acute coronary syndrome
  • Percutaneous coronary intervention

Pharmacology

  • Inhibitor of platelet activation and aggregation
  • Irreversible binding to P2Y12 class of ADP receptors

Dosage & Administration

  • Initial 60 mg oral loading dose
  • Maintenance dose of 10 mg once daily
  • Consider 5 mg once daily for patients <60 kg
  • Aspirin co-administration (75 mg to 325 mg) daily

Interaction

  • Increased risk of bleeding with warfarin co-administration
  • Increased risk of bleeding with NSAIDs (used chronically)
  • Compatibility with cytochrome P450 enzymes inducers/inhibitors
  • Co-administration with aspirin, heparin, GPIIb/IIIa inhibitors, and statins
  • Co-administration with drugs that elevate gastric pH

Contraindications

  • Active pathological bleeding
  • History of prior transient ischemic attack or stroke

Side Effects

  • Bleeding
  • Thrombotic thrombocytopenic purpura
  • Other side effects like headache, back pain, dyspnea, nausea, hypertension, bradycardia, rash

Pregnancy & Lactation

  • Limited evidence in pregnant women
  • Potential risk to nursing infant

Precautions & Warnings

  • Increased risk of CABG-related bleeding
  • Premature discontinuation increases risk of stent thrombosis, MI, and death

Use in Special Populations

  • Limited safety and effectiveness in pediatric patients
  • Increased risk of fatal bleeding events in geriatric patients >75 years
  • No dosage adjustment for renal impairment
  • No dosage adjustment for mild to moderate hepatic impairment

Overdose Effects

  • Lethality observed in rats at high doses
  • Possible restoration of clotting ability with platelet transfusion

Storage Conditions

  • Keep in dry place
  • Away from light and heat
  • Keep out of the reach of children

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