Rocy 5 mg (Tablet)

Indications

• Adjunctive treatment of all forms of parkinsonian syndrome
• Symptomatic treatment of idiopathic, postencephalitic and arteriosclerotic parkinsonian
• Control of extrapyramidal symptoms including pseudoparkinsonian, acute dystonic reactions and akathisia induced by neuroleptic drugs

Pharmacology

• Antimuscarinic antiparkinsonian agent
• Synthetic tertiary amine
• Corrects relative cholinergic excess in parkinsonian due to dopamine deficiency
• Absorbed from G.I. tract
• Acts within 5 to 20 minutes
• Duration of effect up to 4 hours

Dosage & Administration

• Administered orally
• Tablet dosage for parkinsonism: 2.5 mg 3 times a day, then 5 mg 3 times a day, occasionally 5 mg at bedtime
• Tablet dosage for drug induced extrapyramidal symptom: Initially 2.5 mg 3 times a day, increased by 2.5 mg increment per day
• IM or IV injection dosage: 5-10 mg, repeated if necessary after 20 minutes; maximum 20 mg daily

Interaction

• Anticholinergic activity may be increased by certain agents
• Reduction in ketoconazole absorption

Contraindications

• Caution in children and geriatric patients
• Cautious use in patients with diarrhoea, cardiovascular disease, glaucoma, urinary retention, hepatic or renal impairment
• Safety during pregnancy not established
• No data available on drug excretion in breast milk

Side Effects

• Dryness of the mouth at usual dosage levels
• Occasional mydriasis, blurred vision, G.I. effects, allergic reaction, muscular weakness
• High doses may cause vertigo, confusion, and hallucination
• Adverse effects can be minimized by adjustment of dosage and administration after meal

Pregnancy & Lactation

• The safe use in pregnancy, lactation, or in women of childbearing age requires weighing potential benefits against possible hazards

Precautions & Warnings

• Caution in case of hepatic & renal impairment, children, elderly, pregnancy, and lactation
• Avoid abrupt withdrawal to prevent rebound Parkinsonism symptoms
• Potential precipitation of a psychotic episode in patients with mental disorders

Use in Special Populations

• Safety and efficacy not established in pediatric age group

Therapeutic Class

• Antiparkinson drugs

Storage Conditions

• Protect from light and moisture
• Store below 25°C
• Keep out of the reach of children

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