Trixotim 1 gm/vial (IV Injection)

1 gm vial: ৳ 190.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Doctor tims pharmaceuticals ltd

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

3rd generation broad-spectrum parenteral cephalosporin antibiotic

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Usual duration is 4 to 14 days

Administration

  • Intramuscular Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection
    • 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Water for injection
    • 1 g Ceftriaxone in 10 ml of Water for injection USP
    • 2 g Ceftriaxone in 20 ml of Water for injection

Interaction

No drug interactions have been reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects:
    • Diarrhea
    • Nausea
    • Vomiting
    • Stomatitis
    • Glossitis
  • Cutaneous reactions:
    • Rash
    • Pruritus
    • Urticaria
    • Edema
    • Erythema multiforme
  • Hematologic reactions:
    • Eosinophilia
    • Thrombocytopenia
    • Leucopenia
    • Anemia
    • Neutropenia
  • Hepatic reactions:
    • Elevations of SGOT or SGPT
    • Bilirubinemia
  • CNS reactions:
    • Nervousness
    • Confusion
    • Sleep disturbances
    • Headache
    • Dizziness
  • Local phlebitis: Rare following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy has not been established. Low concentrations excreted in human milk.

Precautions & Warnings

  • Potential for anaphylactic shock
  • Anaphylactic shock requires immediate countermeasures
  • Shadows suggesting sludge detected by sonograms of the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Trixotim must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children

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