Liptor EZ 10 mg+10 mg (Tablet)

Indications

• Reduction of elevated total cholesterol
• Reduction of low density lipoprotein cholesterol (LDL-C)
• Reduction of triglycerides (TG)
• Increase of high-density lipoprotein cholesterol (HDL-C)
• Treatment of primary hyperlipidemia
• Treatment of homozygous familial hypercholesterolemia (HoFH)
• Adjunct to diet for atherosclerotic vascular disease
• Adjunct to other lipid lowering treatments
• Reduction of elevated total-C and LDL-C
• Reduction of apolipoprotein B (Apo B)
• Increase of high-density lipoprotein cholesterol (HDL-C)

Pharmacology

• Inhibition of HMG-CoA reductase
• Reduction of LDL production
• Increase of hepatic LDL receptors
• Inhibition of cholesterol absorption by the small intestine
• Molecular target of ezetimibe - Niemann-Pick C1-Like 1 (NPC1L1)
• Reduction of hepatic cholesterol stores
• Increase in clearance of cholesterol from the blood

Dosage & Administration

• Dosage range: 10/10 mg to 80/20 mg daily
• Recommended starting dose: 10/10 mg or 20/10 mg daily
• Recommended starting dose for patients with larger reduction in LDL-C: 40/10 mg daily
• Dosage for patients with homozygous familial hypercholesterolemia: 40/10 mg or 80/10 mg daily
• Administration as a single dose at any time of the day
• Analysis of lipid levels within 2 or more weeks after initiation

Interaction

• Increased risk of myopathy with concurrent administration of fibric acid derivatives
• Risk of myopathy/rhabdomyolysis with gemfibrozil
• Enhanced risk of skeletal muscle effects when used in combination with niacin
• Monitoring recommended for patients taking digoxin
• Consideration of increased AUC values for norethindrone and ethinyl estradiol when selecting an oral contraceptive

Contraindications

• Active liver disease
• Persistent elevations of hepatic transaminase levels
• Hypersensitivity to any component

Side Effects

• Rhabdomyolysis
• Myopathy
• Liver enzyme abnormalities
• Myalgia
• Abdominal pain
• Increased hepatic enzymes

Pregnancy & Lactation

• Pregnancy Category X
• Contraindicated in pregnant women
• Excretion in human milk uncertain
• Discontinuation during pregnancy unlikely to impact long-term outcomes

Precautions & Warnings

• Temporary withholding or discontinuation in case of myopathy
• Liver enzyme tests recommended prior to initiating therapy
• Caution with drugs that may decrease endogenous steroid hormones
• Potentially increased risk of renal failure secondary to rhabdomyolysis

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• No dosage adjustment necessary in geriatric patients

Overdose Effects

• No specific treatment of overdosage recommended
• Symptomatic treatment and supportive measures instituted as required

Therapeutic Class

• Other lipid regulating drugs

Storage Conditions

• Do not store above 30°C
• Keep in a dry place
• Protect from light
• Keep out of the reach of children

Related Brands

• Liptor EZ 20 mg+10 mg (Tablet) - acme-laboratories-ltd
• Atova EZ 10 mg+10 mg (Tablet) - beximco-pharmaceuticals-ltd
• Atova EZ 20 mg+10 mg (Tablet) - beximco-pharmaceuticals-ltd
• Ezitor 10 mg+10 mg (Tablet) - navana-pharmaceuticals-ltd
• Ezitor 20 mg+10 mg (Tablet) - navana-pharmaceuticals-ltd