Atova EZ 10 mg+10 mg (Tablet)

Indications

• Reduction of elevated total cholesterol
• Reduction of low density lipoprotein cholesterol
• Reduction of triglycerides
• Increase in high-density lipoprotein cholesterol
• Indicated for primary hyperlipidemia
• Indicated for homozygous familial hypercholesterolemia
• As an adjunct to diet
• Reduction of non-high-density lipoprotein cholesterol

Pharmacology

• Atorvastatin lowers plasma cholesterol and lipoprotein levels
• Ezetimibe reduces blood cholesterol by inhibiting absorption of cholesterol by the small intestine
• Ezetimibe inhibits intestinal cholesterol absorption by 54%
• Atorvastatin increases the number of hepatic LDL receptors on the cell surface

Dosage & Administration

• Dosage range is 10/10 mg to 80/20 mg daily
• Recommended starting dose is 10/10 mg or 20/10 mg daily
• Can be administered as a single dose at any time of the day, with or without food
• Dosage in patients with homozygous familial hypercholesterolemia is 40/10 mg or 80/10 mg daily
• Regular analysis of lipid levels within 2 or more weeks after initiation

Interaction

• Increased risk of myopathy during treatment with statins
• Coadministration with fibric acid derivatives increases risk of myopathy
• Coadministration with strong CYP3A4 inhibitors enhances risk of skeletal muscle effects

Contraindications

• Active liver disease
• Unexplained persistent elevations of hepatic transaminase levels
• Hypersensitivity to any component

Side Effects

• Rhabdomyolysis
• Myopathy
• Liver enzyme abnormalities
• Myalgia
• Abdominal pain

Pregnancy & Lactation

• Pregnancy Category X
• Contraindicated in women who are or may become pregnant
• Serum cholesterol and triglycerides increase during normal pregnancy
• Not known whether atorvastatin is excreted in human milk

Precautions & Warnings

• Cases of myopathy have been reported, caution with colchicine
• Recommended liver enzyme tests prior to therapy initiation
• Caution if administered concomitantly with drugs that may decrease levels or activity of endogenous steroid hormones

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• No dosage adjustment necessary in geriatric patients

Overdose Effects

• No specific treatment of overdosage can be recommended
• The patient should be treated symptomatically

Therapeutic Class

• Other lipid regulating drugs

Storage Conditions

• Do not store above 30°C
• Keep in a dry place
• Protect from light

Related Brands

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