Empalina 10 mg+5 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Beximco pharmaceuticals ltd
Also available as
Empalina 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases concentration of active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon levels
  • Reduces hepatic glucose output
  • Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Recommended daily dose: 10 mg Empagliflozin and 5 mg Linagliptin
  • Can be taken with or without food
  • Dose may be increased to 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m^2
  • Discontinue if eGFR falls below 45 ml/min/1.73 m^2

Interaction

  • Increased urine volume and frequency with diuretics
  • Increased risk of hypoglycemia with Insulin or Insulin Secretagogues
  • Rifampin decreases Linagliptin exposure
  • Positive urine glucose test with SGLT2 inhibitors
  • Unreliable measurements of 1,5-AG with SGLT2 inhibitors

Contraindications

  • Severe renal impairment, end-stage renal disease, or dialysis
  • Hypersensitivity reaction to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Necrotizing Fasciitis of the Perineum
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters
  • Limited available data in pregnant women
  • Risks associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Pancreatitis
  • Hypotension
  • Acute kidney injury and impairment in renal function
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Genital Mycotic Infections
  • Hypersensitivity
  • Heart Failure

Overdose Effects

  • Contact Poison Control Center in case of overdose
  • Utilize supportive measures based on patient's clinical status

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30°C
  • Keep away from light and wet place
  • Keep out of reach of children

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