Empazin L 10 mg+5 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Delta pharma ltd
Also available as
Empazin l 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon levels
  • Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Increases to 25 mg Empagliflozin and 5 mg Linagliptin once daily can be done
  • Assessment of renal function before initiating the tablet
  • Caution if eGFR is below 45 mL/min/1.73 m^2

Interaction

  • Coadministration with diuretics
  • Coadministration with Insulin or Insulin secretagogues
  • Coadministration with inducers of P-glycoprotein or CYP3A4 Enzymes
  • Increases urinary glucose excretion
  • Interferes with 1,5-anhydroglucitol (1,5-AG) Assay

Contraindications

  • Severe renal impairment or end-stage renal disease
  • History of hypersensitivity reaction to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
  • Necrotizing Fasciitis of the Perineum (Fournier's Gangrene)
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during the second and third trimesters of pregnancy
  • Limited available data in pregnant women

Precautions & Warnings

  • Precaution should be taken in some disease conditions
  • Acute pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Necrotizing Fasciitis of the Perineum (Fournier's Gangrene)
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Heart Failure

Overdose Effects

  • Contact Poison Control Center in case of overdose
  • Usual supportive measures
  • No specific information about hemodialysis

Therapeutic Class

  • SGLT2 Inhibitors

Storage Conditions

  • Store below 30°C
  • Keep away from light and wet place
  • Keep out of reach of children

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