Empazin L 25 mg+5 mg (Tablet)

Unit Price: ৳ 35.00 (3 x 10: ৳ 1,050.00)
Strip Price: ৳ 350.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Delta pharma ltd
Also available as
Empazin l 10 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases concentrations of incretin hormones
  • Stimulates insulin release
  • Decreases glucagon levels
  • Reduces hepatic glucose output
  • Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Increased dose: 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m²
  • Discontinue if eGFR falls below 45 ml/min/1.73 m²

Interaction

  • Coadministration with diuretics
  • Coadministration with Insulin or Insulin secretagogues
  • Effect on P-glycoprotein or CYP3A4 Enzymes
  • Positive urine glucose test
  • Interference with 1,5-anhydroglucitol (1,5-AG) Assay

Contraindications

  • Severe renal impairment
  • End-stage renal disease or dialysis
  • Hypersensitivity reaction to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
  • Necrotizing Fasciitis of the Perineum
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters of pregnancy
  • Limited available data in pregnant women
  • Risks associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Pancreatitis
  • Hypotension
  • Acute kidney injury and impairment in renal function
  • Hypoglycemia
  • Genital Mycotic Infections
  • Hypersensitivity
  • Heart Failure

Overdose Effects

  • Contact Poison Control Center
  • Employ supportive measures
  • Removal of unabsorbed material from the gastrointestinal tract
  • Clinical monitoring
  • Institute supportive treatment

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30°C
  • Keep away from light and wet place
  • Keep out of reach of children

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