Glympa 10 mg+5 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Square pharmaceuticals plc
Also available as
Glympa 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases concentration of incretin hormones
  • Stimulates insulin release
  • Decreases glucagon levels
  • Reduces hepatic glucose output
  • Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Recommended dose of 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Taken in the morning
  • Dose may be increased to 25 mg Empagliflozin and 5 mg Linagliptin once daily for some patients
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m^2
  • Discontinue if eGFR falls below 45 ml/min/1.73 m^2

Interaction

  • Coadministration with diuretics increases urine volume and frequency of voids
  • Increases potential for volume depletion
  • Increases risk for hypoglycemia when coadministered with Insulin or Insulin secretagogues
  • Rifampin decreases Linagliptin exposure
  • SGLT2 inhibitors lead to positive urine glucose tests
  • Measurements of 1,5-anhydroglucitol (1,5-AG) are unreliable in assessing glycemic control

Contraindications

  • Severe renal impairment, end-stage renal disease, or dialysis
  • Hypersensitivity reaction to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
  • Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene)
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during the second and third trimesters of pregnancy
  • Limited available data in pregnant women
  • Risks associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Precautions in disease conditions like Pancreatitis, Hypotension, Ketoacidosis, Acute kidney injury, Urosepsis and Pyelonephritis, Hypoglycemia, Genital Mycotic Infections, Hypersensitivity
  • Reports of acute pancreatitis, including fatal cases
  • Reports of ketoacidosis, including fatal cases
  • Intravascular volume depletion
  • Increased risk for urinary tract infections
  • Hypoglycemia with Concomitant Use with Insulin & Insulin Secretagogues
  • Reports of necrotizing fasciitis of the perineum (Fournier’s gangrene)
  • Increases risk for genital mycotic infections
  • Heart failure observed in cardiovascular outcomes trials

Overdose Effects

  • Contact Poison Control Center in case of overdose
  • Employ usual supportive measures
  • Removal by hemodialysis not studied

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30° C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

Related Brands