Glympa 25 mg+5 mg (Tablet)

Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Square pharmaceuticals plc
Also available as
Glympa 10 mg tablet

Indications

  • Adjunct to diet and exercise
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibition of DPP-4 enzyme
  • Increase in active incretin hormones
  • Stimulation of insulin release
  • Reduction in glucagon levels
  • Inhibition of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduction in renal reabsorption of glucose
  • Increase in urinary glucose excretion

Dosage & Administration

  • Recommended daily dose of 10mg Empagliflozin and 5mg Linagliptin
  • Increased dose possibility to 25mg Empagliflozin and 5mg Linagliptin
  • Assessment of renal function before initiation

Interaction

  • Coadministration with diuretics leading to increased urine volume
  • Increased risk for hypoglycemia with Insulin or Insulin secretagogues
  • Potential reduction in efficacy when administered with strong P-gp or CYP3A4 inducers

Contraindications

  • Severe renal impairment
  • Hypersensitivity reactions
  • End-stage renal disease or dialysis

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Necrotizing Fasciitis of the Perineum
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters of pregnancy
  • Limited available data in pregnant women

Precautions & Warnings

  • Precaution in disease conditions like Pancreatitis, Hypotension, Ketoacidosis, Acute kidney injury and impairment in renal function, Urosepsis and Pyelonephritis, Genital Mycotic Infections, Hypersensitivity
  • Reports of ketoacidosis and volume depletion
  • Increased risk for urosepsis and pyelonephritis
  • Hypoglycemia with concomitant use of Insulin & Insulin Secretagogues
  • Risks of necrotizing fasciitis of the perineum
  • Increased risk for heart failure

Overdose Effects

  • Contact Poison Control Center in case of overdose
  • Employ supportive measures as dictated by patient’s clinical status

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30°C
  • Keep away from light and wet place
  • Keep out of reach of children

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