Glympa 25 mg+5 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
Category | Details |
---|---|
Generic | Empagliflozin linagliptin |
Company | Square pharmaceuticals plc |
Also available as |
Indications
- Adjunct to diet and exercise
- Type 2 diabetes mellitus
Pharmacology
- Inhibition of DPP-4 enzyme
- Increase in active incretin hormones
- Stimulation of insulin release
- Reduction in glucagon levels
- Inhibition of Sodium-glucose co-transporter 2 (SGLT2)
- Reduction in renal reabsorption of glucose
- Increase in urinary glucose excretion
Dosage & Administration
- Recommended daily dose of 10mg Empagliflozin and 5mg Linagliptin
- Increased dose possibility to 25mg Empagliflozin and 5mg Linagliptin
- Assessment of renal function before initiation
Interaction
- Coadministration with diuretics leading to increased urine volume
- Increased risk for hypoglycemia with Insulin or Insulin secretagogues
- Potential reduction in efficacy when administered with strong P-gp or CYP3A4 inducers
Contraindications
- Severe renal impairment
- Hypersensitivity reactions
- End-stage renal disease or dialysis
Side Effects
- Pancreatitis
- Ketoacidosis
- Volume Depletion
- Urosepsis and Pyelonephritis
- Hypoglycemia
- Necrotizing Fasciitis of the Perineum
- Genital Mycotic Infections
- Hypersensitivity Reactions
- Severe and Disabling Arthralgia
- Bullous Pemphigoid
- Heart Failure
Pregnancy & Lactation
- Not recommended during second and third trimesters of pregnancy
- Limited available data in pregnant women
Precautions & Warnings
- Precaution in disease conditions like Pancreatitis, Hypotension, Ketoacidosis, Acute kidney injury and impairment in renal function, Urosepsis and Pyelonephritis, Genital Mycotic Infections, Hypersensitivity
- Reports of ketoacidosis and volume depletion
- Increased risk for urosepsis and pyelonephritis
- Hypoglycemia with concomitant use of Insulin & Insulin Secretagogues
- Risks of necrotizing fasciitis of the perineum
- Increased risk for heart failure
Overdose Effects
- Contact Poison Control Center in case of overdose
- Employ supportive measures as dictated by patient’s clinical status
Therapeutic Class
- Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors
Storage Conditions
- Store below 30°C
- Keep away from light and wet place
- Keep out of reach of children