Glyxam 10 mg+5 mg (Tablet)

Unit Price: ৳ 35.00 (2 x 10: ৳ 700.00)
Strip Price: ৳ 350.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Popular pharmaceuticals ltd
Also available as
Glyxam 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases concentration of active incretin hormones
  • Stimulates insulin release in a glucose-dependent manner
  • Decreases glucagon levels
  • Regulates glucose homeostasis
  • Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Dose may be increased to 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m2
  • Discontinue if eGFR falls below 45 ml/min/1.73 m2

Interaction

  • Increased urine volume and frequency of voids with diuretics
  • Risk for hypoglycemia with Insulin or Insulin secretagogues
  • Reduced efficacy when administered with strong P-gp or CYP3A4 inducer
  • Positive urine glucose test due to increased urinary glucose excretion
  • Unreliable assessment of glycemic control with 1,5-AG assay

Contraindications

  • Severe renal impairment
  • End-stage renal disease
  • Hypersensitivity reaction to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Necrotizing Fasciitis of the Perineum
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters of pregnancy
  • Limited available data in pregnant women
  • Risks associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Precaution in diseases like Pancreatitis, Hypotension, Ketoacidosis, Acute kidney injury
  • Increased risk for urinary tract infections
  • Possible genital mycotic infections
  • Association with heart failure observed in trials

Overdose Effects

  • Contact Poison Control Center in case of overdose
  • Employ usual supportive measures
  • Removal of Empagliflozin by hemodialysis not studied
  • Removal of Linagliptin by hemodialysis or peritoneal dialysis unlikely

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30°C
  • Keep away from light and wet place
  • Keep out of reach of children

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