Prapid 5 mg (Tablet)

Unit Price: ৳ 12.05 (2 x 10: ৳ 241.00)
Strip Price: ৳ 120.50

Medicine Details

Category Details
Generic Prasugrel hydrochloride
Company Drug international ltd
Also available as
Prapid 10 mg tablet

Indications

  • Reduce rate of thrombotic cardiovascular events
  • Manage with percutaneous coronary intervention
  • Unstable angina
  • Non-ST-elevation myocardial infarction
  • ST-elevation myocardial infarction

Pharmacology

  • Inhibitor of platelet activation and aggregation
  • Irreversible binding to P2Y12 class of ADP receptors

Dosage & Administration

  • Initiate with 60 mg oral loading dose
  • Continue at 10 mg once daily
  • Consider 5 mg once daily for patients <60 kg
  • Take with or without food
  • Co-administer with aspirin (75 mg to 325 mg) daily

Interaction

  • Increase risk of bleeding with warfarin
  • Increase risk of bleeding with NSAIDs
  • Administer with inducers or inhibitors of cytochrome P450 enzymes
  • Administer with aspirin, heparin, GPIIb/IIIa inhibitors, statins, and drugs that elevate gastric pH

Contraindications

  • Active pathological bleeding
  • History of prior transient ischemic attack or stroke

Side Effects

  • Bleeding
  • Thrombotic thrombocytopenic purpura
  • Headache
  • Back pain
  • Dyspnea
  • Nausea
  • Hypertension
  • Bradycardia
  • Rash

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Not known if excreted in human milk
  • Use during nursing only if benefit justifies potential risk to the nursing infant

Precautions & Warnings

  • Increased risk of bleeding in patients undergoing CABG
  • Premature discontinuation increases risk of stent thrombosis, MI, and death

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • Increased risk of fatal bleeding events in geriatric patients > 75 years
  • No dosage adjustment for renal impairment
  • No dosage adjustment for mild to moderate hepatic impairment

Overdose Effects

  • Lethality observed after administration of 2000 mg/kg in rats
  • Platelet transfusion may restore clotting ability

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep in dry place
  • Keep away from light and heat
  • Keep out of the reach of children

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