Emjenta 25 mg+5 mg (Tablet)

Unit Price: ৳ 50.00 (1 x 10: ৳ 500.00)
Strip Price: ৳ 500.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Nipro jmi pharma ltd
Also available as
Emjenta 10 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases active incretin hormones
  • Stimulates insulin release
  • Reduces glucagon levels
  • Reduces hepatic glucose output
  • Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Can be taken with or without food
  • Increased dose: 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function in renal impaired patients
  • Do not initiate if eGFR is below 45 mL/min/1.73 m2

Interaction

  • Coadministration with diuretics increases urine volume
  • Coadministration with Insulin or Insulin secretagogues increases risk for hypoglycemia
  • Rifampin decreases Linagliptin exposure
  • Positive urine glucose test due to SGLT2 inhibitors
  • Interference with 1,5-anhydroglucitol (1,5-AG) Assay

Contraindications

  • Severe renal impairment
  • End-stage renal disease
  • Dialysis
  • Hypersensitivity reaction to Linagliptin
  • Hypersensitivity reaction to Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
  • Necrotizing Fasciitis of the Perineum
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters
  • Limited data in pregnant women
  • Risks associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Precaution in Pancreatitis, Hypotension, Ketoacidosis, Acute kidney injury, Genital Mycotic Infections, Hypersensitivity, Heart Failure
  • Reports of acute pancreatitis and fatal pancreatitis
  • Increased risk for urinary tract infections
  • Hypoglycemia with Concomitant Use with Insulin
  • Reports of necrotizing fasciitis of the perineum
  • Increased risk for heart failure

Overdose Effects

  • Contact Poison Control Center
  • Use usual supportive measures
  • Remove unabsorbed material from the gastrointestinal tract
  • Clinical monitoring
  • Institute supportive treatment

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30° C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

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