D-1000 1000 IU (Tablet)
Unit Price: ৳ 2.00 (5 x 10: ৳ 100.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cholecalciferol vitamin d3 |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Title & Categories
- Vitamin D3 Supplement
- Bone Health Supplements
Description
- Essential for calcium and phosphate absorption
- Prevents rickets, osteomalacia, and osteoporosis
- Aids in preventing pre-eclampsia during pregnancy
- Boosts immunity
- Contains Calcitriol - the active form of Vitamin D3
- Absorbed in the small intestine
- Metabolized to 25-hydroxy Vitamin D3 (Calcidiol) in the liver
- Metabolism to 1,25-dihydroxy Vitamin D3 (Calcitriol) occurs in the kidney
- Stored in tissues such as fat and muscle
- Eliminated via feces and urine
- Interacts with Magnesium containing Antacids, Digoxin, Thiazide Diuretics, Cholestyramine, Cholistipol, Phenytoin, Phenobarbital, Orlistat, Mineral Oil, and Corticosteroids
- Contraindicated in diseases associated with hypercalcemia
- Contraindicated in patients with known hypersensitivity to Vitamin D3
- Contraindicated in evidence of Vitamin D3 toxicity
- Symptoms of overdose include hypervitaminosis D
Indications
- Prevention and treatment of Vitamin D3 deficiency
- Essential for healthy bones, teeth, and infant growth
- Vital for immunity boost
Pharmacology
- Binds to Vitamin D receptors (VDRs)
- Half-life of about 50 days as it is fat-soluble
- Requires measurement of 25 hydroxyvitamin D for maintenance therapy confirmation
- Increases calcium absorption
Dosage & Administration
- For adults: varying doses for treatment, prevention, and specific therapy for osteoporosis
- For children (12-18 years): varying doses for treatment and prevention
- Different dosage forms such as capsule, film-coated tablet, oroflash or chewable tablets, syrup, and injection
Interaction
- Interacts with various drugs leading to deficiencies and increased need
Contraindications
- Contraindicated in diseases associated with hypercalcaemia
- Contraindicated in patients with known hypersensitivity to Vitamin D3
- Contraindicated in evidence of Vitamin D3 toxicity
Side Effects
- Anorexia
- Lassitude
- Nausea & vomiting
- Diarrhea
- Constipation
- Weight loss
- Polyuria
- Sweating
- Headache
- Thirst
- Vertigo
- Raised concentrations of calcium and phosphate in plasma and urine
Pregnancy & Lactation
- Safe use of doses up to 4000 IU during pregnancy
- Recommended daily intake for pregnant women is 400 IU
- Excreted in breast milk
- Overdose in infants induced by nursing mothers has not been observed
Precautions & Warnings
- Plasma-calcium concentration should be monitored at intervals
- Consultation required in renal impairment, pregnancy, and lactation
- Patients using Digoxin and Thiazide Diuretics should consult a health care practitioner before supplementing
Use in Special Populations
- Safety & efficacy not established in children under 12 years
Overdose Effects
- Can lead to hypervitaminosis D
Therapeutic Class
- Vitamin in bone formation
- Vitamin-D preparations
Storage Conditions
- Keep below 30° C temperature
- Protected from light & moisture
- Keep out of the reach of children