Prasulet 5 mg (Tablet)

Unit Price: ৳ 12.04 (3 x 10: ৳ 361.20)
Strip Price: ৳ 120.40

Medicine Details

Category Details
Generic Prasugrel hydrochloride
Company Beacon pharmaceuticals plc
Also available as
Prasulet 10 mg tablet

Indications

  • Reduces rate of thrombotic cardiovascular (CV) events
  • Management with percutaneous coronary intervention (PCI)
  • Unstable angina (UA) or non-ST-elevation myocardial infarction (NSTEMI)
  • ST-elevation myocardial infarction (STEMI) when managed with primary or delayed PCI

Pharmacology

  • Inhibitor of platelet activation and aggregation
  • Irreversible binding to P2Y12 class of ADP receptors on platelets

Dosage & Administration

  • 60 mg oral loading dose
  • 10 mg once daily (with or without food)
  • Consider 5 mg once daily for patients <60 kg
  • Take with aspirin (75 mg to 325 mg) daily

Interaction

  • Increases risk of bleeding when coadministered with warfarin
  • May increase risk of bleeding when coadministered with NSAIDs
  • Can be administered with drugs that are inducers or inhibitors of cytochrome P450 enzymes
  • Can be administered with aspirin, heparin, GPIIb/IIIa inhibitors, statins, and drugs that elevate gastric pH

Contraindications

  • Active pathological bleeding such as peptic ulcer or intracranial haemorrhage
  • History of prior transient ischemic attack or stroke

Side Effects

  • Bleeding
  • Thrombotic thrombocytopenic purpura
  • Headache
  • Back pain
  • Dyspnea
  • Nausea
  • Hypertension
  • Bradycardia
  • Rash

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Not known whether excreted in human milk
  • Use during nursing only if potential benefit justifies potential risk to the nursing infant

Precautions & Warnings

  • Increased risk of bleeding in patients receiving who undergo CABG
  • Premature discontinuation increases risk of stent thrombosis, MI, and death

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • Increased risk of fatal bleeding events in patients > 75 years of age
  • No dosage adjustment necessary for patients with renal impairment
  • Limited experience in patients with end-stage renal disease
  • No dosage adjustment necessary in patients with mild to moderate hepatic impairment

Overdose Effects

  • Lethality observed in rats after administration of 2000 mg/kg
  • Platelet transfusion may restore clotting ability
  • Prasugrel active metabolite not likely to be removed by dialysis

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep in dry place
  • Away from light and heat
  • Keep out of the reach of children

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