Elipta 10 mg+5 mg (Tablet)
Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin linagliptin |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for type 2 diabetes mellitus
Pharmacology
- Inhibition of DPP-4 enzyme
- Increase in active incretin hormones
- Stimulation of insulin release
- Decrease in glucagon levels
- Regulation of glucose homeostasis
- Inhibition of Sodium-glucose co-transporter 2 (SGLT2)
- Reduction of renal reabsorption of glucose
- Increase in urinary glucose excretion
Dosage & Administration
- Recommended daily dose of 10 mg Empagliflozin and 5 mg Linagliptin
- Increased dosage option
- Assessment of renal function before initiation
Interaction
- Effect of diuretics on urine volume and frequency
- Increased risk of hypoglycemia with insulin or insulin secretagogues
- Effect of inducers of P-glycoprotein or CYP3A4 enzymes on Linagliptin exposure
- SGLT2 inhibitors' impact on urine glucose tests
- Unreliable 1,5-anhydroglucitol (1,5-AG) assay in patients taking SGLT2 inhibitors
Contraindications
- Severe renal impairment, end-stage renal disease, or dialysis
- Hypersensitivity reactions to Linagliptin or Empagliflozin
Side Effects
- Pancreatitis
- Ketoacidosis
- Volume Depletion
- Urosepsis and Pyelonephritis
- Hypoglycemia
- Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene)
- Genital Mycotic Infections
- Hypersensitivity Reactions
- Severe and Disabling Arthralgia
- Bullous Pemphigoid
- Heart Failure
Pregnancy & Lactation
- Not recommended during the second and third trimesters
- Limited data on pregnant women
Precautions & Warnings
- Precautions for Pancreatitis, Hypotension, Ketoacidosis, Acute kidney injury, Urosepsis, Hypoglycemia, Genital Mycotic Infections, Hypersensitivity
- Reports of ketoacidosis and pancreatitis
- Risk of volume depletion and hypotension
- Increased risk for urinary tract infections
- Hypoglycemia with concomitant use of insulin and insulin secretagogues
- Rare but serious necrotizing infection (Fournier’s Gangrene)
- Increased risk for genital mycotic infections
- Observation of heart failure in DPP-4 inhibitor treatment
Overdose Effects
- Contact Poison Control Center in case of overdose
- Employ supportive measures
Therapeutic Class
- Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors
Storage Conditions
- Storage below 30°C
- Protection from light and moisture
- Keep away from children