Pegalin ER 165 mg (Tablet (Extended Release))

Unit Price: ৳ 35.00 (3 x 10: ৳ 1,050.00)
Strip Price: ৳ 350.00

Medicine Details

Category Details
Generic Pregabalin
Company Popular pharmaceuticals ltd
Also available as
Pegalin 25 mg capsule Pegalin 50 mg capsule Pegalin 75 mg capsule Pegalin 100 mg capsule Pegalin 150 mg capsule Pegalin er 825 mg tablet Pegalin er 330 mg tablet

Indications

  • Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
  • Postherpetic neuralgia (PHN)
  • Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
  • Fibromyalgia
  • Neuropathic pain associated with spinal cord injury

Pharmacology

  • Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Binds with high affinity to the alpha2-delta site in central nervous system tissues
  • Mechanism of action not fully elucidated
  • Results in animal studies suggest anti-nociceptive and antiseizure effects

Dosage

  • Maximum recommended dose for diabetic peripheral neuropathy: 100 mg three times a day
  • Maximum recommended dose for postherpetic neuralgia: 75 to 150 mg two times a day or 50 to 100 mg three times a day
  • Recommended dose for fibromyalgia: 300 to 450 mg/day
  • Recommended dose range for neuropathic pain associated with spinal cord injury: 150 to 600 mg/day
  • Dosage form conversion guidance
  • Pregabalin tablet total daily dose vs Pregabalin CR capsule dose

Administration

  • Route of administration: Oral, with or without food
  • Pregabalin CR tablet administration after an evening meal
  • Guidance on missed doses and discontinuation

Interaction

  • Unlikely to be involved in significant pharmacokinetic drug interactions
  • No significant drug interaction with food and others

Contraindications

  • Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side Effects

  • Common side effects in adults: dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal
  • Common side effects in pediatric patients for the treatment of partial onset seizures: increased weight and increased appetite

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Potential risk to fetus
  • Small amounts detected in the milk of lactating women
  • Breastfeeding not recommended

Precautions & Warnings

  • Potential occurrence of angioedema
  • Discontinuation and monitoring in case of hypersensitivity reactions
  • Increased risk of suicidal thoughts or behavior
  • Possible respiratory depression when used with concomitant CNS depressants or in the setting of underlying respiratory impairment
  • Potential to cause dizziness, somnolence, and impaired ability to drive or operate machinery
  • Need for gradual withdrawal over a minimum of 1 week

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients for certain indications

Overdose Effects

  • Signs and symptoms of overdose
  • No specific antidote
  • General supportive care indicated, including monitoring of vital signs

Therapeutic Class

  • Adjunct anti-epileptic drugs
  • Primary anti-epileptic drugs

Storage Conditions

  • Keep in a cool & dry place (below 30°C)
  • Protected from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C8H17NO2
  • Chemical Structure image available

Common Questions about Pegalin ER 165 mg Tablet

  • Description of the medication
  • Duration required to see improvement in condition
  • Frequency of usage
  • Instructions for storage and disposal
  • Varied mechanisms of action for different diseases

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