Pronex-MUPS 40 mg (MUPS Tablet)
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole mups preparation |
| Company | Drug international ltd |
| Also available as |
Title and Categories
- Pronex-MUPS 40 mg Tablet
- Medicine
- Proton Pump Inhibitor
- Gastrointestinal Medication
- Pharmaceutical Product
Indications
- Treatment of Gastro-esophageal Reflux Disease (GERD)
- Risk reduction in NSAID associated gastric ulcer
- H. pylori eradication (Triple therapy)
- Treatment of Zollinger-Ellison syndrome and idiopathic hypersecretion
Composition
- Esomeprazole MUPS 20 Tablet containing 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
- Esomeprazole MUPS 40 Tablet containing 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
Dosage
- Erosive esophagitis:
- Adult (≥18 years): 40 mg once daily for 4 weeks
- Children & adolescents (12-18 years): 40 mg once daily for 4 weeks
- Maintenance of healing of erosive esophagitis:
- Adult (≥18 years): 20 mg once daily
- Children & adolescents (12-18 years): 20 mg once daily
- Risk reduction in NSAID associated gastric ulcer: Adult (≥18 years): 20 mg once daily for 4-8 weeks
- H. pylori eradication:
- Adult (≥18 years): 20 mg twice daily for 7 days
- Children & adolescents (12-18 years): 20 mg twice daily for 7 days
- Zollinger-Ellison syndrome and idiopathic hypersecretion: Adult (≥18 years): 40-80 mg twice daily
Administration
Tablets should be swallowed whole with liquid, can be dispersed in non-carbonated water if required, should not be chewed or crushed
Interaction
- Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
- CYP Inhibition: May potentially interfere with CYP2C19
- Gastric pH Interference: May interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
- Combination Therapy with Clarithromycin: May result in increases in the plasma levels of Pronex-MUPS and 14-hydroxyclarithromycin
Contraindications
Contraindicated in patients with known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
Manufacturer advises caution; presence in human breast milk is not known
Precautions & Warnings
- Use with caution in severe liver dysfunction
- Use with caution in severe renal impairment
- May slightly increase the risk of hip, wrist, and spine fracture, particularly when taken for more than one year
Storage Conditions
Store below 25ºC, protect from light, keep out of reach of children
Compound Summary
- Molecular Formula: C17H19N3O3S
- Chemical Structure: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg