Epizol-N 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Nipa pharmaceuticals ltd
Also available as
Epizol n 500 mg tablet

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Naproxen is a NSAID with analgesic & antipyretic properties
  • Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion

Dosage

  • Use the lowest effective dose
  • One tablet twice daily for adults
  • Different doses for Juvenile Idiopathic Arthritis in Adolescent Patients based on weight

Administration

  • To be taken at least 30 minutes before meals
  • Do not split, chew, crush, or dissolve the tablet

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use with warfarin may result in an increased risk of a bleeding complication
  • Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

  • Known hypersensitivity to any component
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of CABG surgery

Side Effects

  • Decrease the occurrence of gastric ulcers and NSAID-associated upper gastrointestinal adverse events
  • Increased risk of arterial thrombotic events with high doses and long-term treatment
  • Gastrointestinal events like peptic ulcers, perforation or GI bleeding
  • Other gastrointestinal side effects like nausea, vomiting, diarrhea, etc.

Pregnancy & Lactation

  • Not recommended during the first and second trimester of pregnancy
  • Contraindicated during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • NSAIDs may impair female fertility

Precautions & Warnings

  • Avoid combining with other NSAIDs
  • Used with low dose acetylsalicylic acid
  • Increased risk of gastrointestinal infections with proton pump inhibitors
  • May reduce the absorption of vitamin B12
  • Appropriate monitoring for patients with hypertension, heart failure, renal impairments, etc.

Use in Special Populations

  • Use caution and dose adjustment in elderly patients
  • Not recommended for use in patients with moderate to severe or severe renal impairment
  • Close monitoring and possible dose reduction for patients with hepatic insufficiency

Overdose Effects

  • Symptoms related to naproxen and esomeprazole overdose
  • Management including symptomatic and supportive care, emesis, activated charcoal, and general supportive measures

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature of below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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