Lyrinex CR 165 mg (Tablet (Extended Release))
Unit Price: ৳ 25.00 (3 x 8: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
- Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
- Binds with high affinity to the alpha2-delta site in central nervous system tissues
- Mechanism of action not fully elucidated
Dosage
- Maximum recommended dose of 100 mg three times a day for neuropathic pain associated with DPN
- Recommended dose of 75 to 150 mg two times a day for PHN
- Recommended dose of 300 to 450 mg/day for fibromyalgia
- Recommended dose range of 150 to 600 mg/day for neuropathic pain associated with spinal cord injury
Administration
- Oral route of administration
- Can be taken with or without food
- Pregabalin CR tablet should be administered after an evening meal
- Should be swallowed whole and not split, crushed or chewed
- Discontinuation should be gradual over a minimum of 1 week
Interaction
- Lyrinex CR is unlikely to be involved in significant pharmacokinetic drug interactions
- No significant drug interaction with food and others
Contraindications
- Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components
Side Effects
- Common side effects in adults: dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal
- Common side effects in pediatric patients: increased weight, increased appetite
- Potential risk to fetus
- Small amounts detected in the milk of lactating women
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Potential risk of tumorigenicity
- Breastfeeding not recommended during treatment
Precautions & Warnings
- Angioedema can occur and may be associated with life-threatening respiratory compromise
- Hypersensitivity reactions should lead to discontinuation
- Increased risk of suicidal thoughts or behavior
- Respiratory depression may occur when used with concomitant CNS depressants
- May cause dizziness and somnolence
- Increased seizure frequency or other adverse reactions may occur if rapidly discontinued
- May cause peripheral edema
Use in Special Populations
- Safety and effectiveness not established in pediatric patients for various indications
Overdose Effects
- Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, heart block
- No specific antidote
Therapeutic Class
- Adjunct anti-epileptic drugs
- Primary anti-epileptic drugs
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C8H17NO2
Common Questions
- Lyrinex CR 165 mg XR Tablet is an anticonvulsant and first-line treatment for neuropathic pain, shingles, seizures, and fibromyalgia
- Dosage should be continued until improvement is observed
- Should be taken after food in prescribed dosage
- Storage and disposal instructions should be followed
- Works differently for different diseases
- Consult the doctor before stopping the medication
- Can be used with Diazepam
- May cause weight gain; consult a dietician for concerns
Quick Tips
- Should be taken as per the dose and duration prescribed
- May cause sleepiness; avoid activities requiring concentration
- May cause blurring or loss of vision; inform the doctor immediately
- Report any unusual changes in mood or behavior
- Do not stop suddenly without consulting the doctor