Lyrinex CR 165 mg (Tablet (Extended Release))

Unit Price: ৳ 25.00 (3 x 8: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Pregabalin
Company Nipro jmi pharma ltd
Also available as
Lyrinex 50 mg capsule Lyrinex 75 mg capsule Lyrinex 150 mg capsule Lyrinex cr 825 mg tablet

Indications

  • Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
  • Postherpetic neuralgia (PHN)
  • Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
  • Fibromyalgia
  • Neuropathic pain associated with spinal cord injury

Pharmacology

  • Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Binds with high affinity to the alpha2-delta site in central nervous system tissues
  • Mechanism of action not fully elucidated

Dosage

  • Maximum recommended dose of 100 mg three times a day for neuropathic pain associated with DPN
  • Recommended dose of 75 to 150 mg two times a day for PHN
  • Recommended dose of 300 to 450 mg/day for fibromyalgia
  • Recommended dose range of 150 to 600 mg/day for neuropathic pain associated with spinal cord injury

Administration

  • Oral route of administration
  • Can be taken with or without food
  • Pregabalin CR tablet should be administered after an evening meal
  • Should be swallowed whole and not split, crushed or chewed
  • Discontinuation should be gradual over a minimum of 1 week

Interaction

  • Lyrinex CR is unlikely to be involved in significant pharmacokinetic drug interactions
  • No significant drug interaction with food and others

Contraindications

  • Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side Effects

  • Common side effects in adults: dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal
  • Common side effects in pediatric patients: increased weight, increased appetite
  • Potential risk to fetus
  • Small amounts detected in the milk of lactating women

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Potential risk of tumorigenicity
  • Breastfeeding not recommended during treatment

Precautions & Warnings

  • Angioedema can occur and may be associated with life-threatening respiratory compromise
  • Hypersensitivity reactions should lead to discontinuation
  • Increased risk of suicidal thoughts or behavior
  • Respiratory depression may occur when used with concomitant CNS depressants
  • May cause dizziness and somnolence
  • Increased seizure frequency or other adverse reactions may occur if rapidly discontinued
  • May cause peripheral edema

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients for various indications

Overdose Effects

  • Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, heart block
  • No specific antidote

Therapeutic Class

  • Adjunct anti-epileptic drugs
  • Primary anti-epileptic drugs

Storage Conditions

  • Keep in a cool & dry place (below 30°C)
  • Protected from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C8H17NO2

Common Questions

  • Lyrinex CR 165 mg XR Tablet is an anticonvulsant and first-line treatment for neuropathic pain, shingles, seizures, and fibromyalgia
  • Dosage should be continued until improvement is observed
  • Should be taken after food in prescribed dosage
  • Storage and disposal instructions should be followed
  • Works differently for different diseases
  • Consult the doctor before stopping the medication
  • Can be used with Diazepam
  • May cause weight gain; consult a dietician for concerns

Quick Tips

  • Should be taken as per the dose and duration prescribed
  • May cause sleepiness; avoid activities requiring concentration
  • May cause blurring or loss of vision; inform the doctor immediately
  • Report any unusual changes in mood or behavior
  • Do not stop suddenly without consulting the doctor

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