Trexall 10 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Methotrexate
Company Healthcare pharmaceuticals ltd
Also available as
Trexall 50 mg injection Trexall 25 mg tablet

Indications

  • Treatment of gestational choriocarcinoma
  • Treatment of acute lymphoblastic leukemia
  • Treatment of non-Hodgkin lymphomas
  • Management of severe rheumatoid arthritis
  • Symptomatic control of severe psoriasis

Pharmacology

Inhibits dihydrofolic acid reductase, interferes with DNA synthesis, repair, and cellular replication, more sensitive to malignant cells

Dosage

  • Choriocarcinoma and similar trophoblastic diseases: 15-30 mg daily for a five-day course, repeated 3-5 times
  • Acute Lymphoblastic Leukemia:
    • Induction dose: 3.3 mg/m2 in combination with prednisone 60 mg/m2 daily for 4-6 weeks
    • Maintenance dose: 30 mg/m2 weekly
  • Lymphoma: Variable dosage depending on tumor type and stage
  • Breast Cancer: 40 mg/m2 intravenously on specific days in combination with other drugs
  • Rheumatoid Arthritis: Single doses of 7.5-20 mg weekly
  • Polyarticular-Course Juvenile Rheumatoid Arthritis: 10 mg/m2 once weekly
  • Psoriasis: 10-30 mg once weekly

Administration

Best taken on an empty stomach, may be taken with meals to reduce GI discomfort, avoid taking with milk-rich products

Interaction

  • NSAIDs: Should not be administered prior to or concomitantly with high doses
  • Salicylates, Phenylbutazone, Phenytoin and Sulfonamides: Increased toxicity
  • Cisplatin: Caution must be exercised if administered with high-dose Trexall
  • Mercaptopurine: Increases the plasma levels
  • Vitamin preparations containing folic acid or its derivatives: Decreases responses to systemically administered Trexall

Contraindications

  • Alcoholism or chronic liver disease
  • Immunodeficiency syndromes
  • Pre-existing blood dyscrasias
  • Hypersensitivity to methotrexate
  • Pregnant or nursing women

Side Effects

  • Ulcerative stomatitis
  • Leukopenia
  • Nausea
  • Abdominal distress
  • Malaise
  • Fatigue
  • Chills
  • Fever
  • Dizziness
  • Decreased resistance to infection

Pregnancy & Lactation

US FDA Pregnancy Category X, contraindicated in nursing mothers

Precautions & Warnings

  • Trexall formulations and diluents containing preservatives must not be used for intrathecal or high dose therapy
  • Follow patients closely for toxic effects
  • Reduce dosage or discontinue if adverse reactions occur
  • Persistent liver function test abnormalities may be indicators of serious liver toxicity

Use in Special Populations

  • Pediatric patients: Weigh benefits against potential risk
  • Geriatric patients: Closely monitor for early signs of hepatic, bone marrow, and renal toxicity

Overdose Effects

Leucovorin is indicated to diminish the toxicity and counteract the effect of inadvertently administered overdosages

Therapeutic Class

Antidote preparations, Immunosuppressant

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture

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