Vorifast 50 mg (Tablet)
Unit Price: ৳ 50.00 (1 x 10: ৳ 500.00)
Strip Price: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Invasive aspergillosis
- Candidemia
- Disseminated candidiasis
- Esophageal candidiasis
- Serious infections by Scedosporium apiospermum
- Fusarium species infections
- Refractory to other therapy
Pharmacological Action
- Binds and inhibits ergosterol synthesis
- Inhibits CYP450-dependent 14-alpha sterol demethylase
- Results in depletion of ergosterol in fungal cell membrane
Dosage and Administration
- Oral administration
- Consists of loading and maintenance doses
- Dosing based on body weight
- Instructions for use in invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis
Interactions
- Interaction with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- Potential increase in concentrations and activity of drugs
- Dosage adjustment with co-administration of Phenytoin or Efavirenz
Contraindications
- Known hypersensitivity to Voriconazole or its components
- Co-administration with specific drugs due to risk of serious adverse reactions
Side Effects
- Abdominal pain
- Anemia
- Blurred vision
- Headache
- Chest pain
- Nausea
- Diarrhea
Pregnancy and Lactation
- Limited studies in pregnant women
- Use during pregnancy requires assessment of potential benefit and risk
Precautions and Warnings
- Careful assessment for long-term use exceeding 180 days
- Reported association with squamous cell carcinoma of the skin
Use in Special Populations
- Efficacy not established in children under 12 years of age
Overdose Effects
- No available data on overdose effects
Therapeutic Class
- Other Antifungal preparations
Reconstitution Instructions
- Shake the bottle well before adding water to loosen the powder
- Specific measurement of water to be added
- Storage instructions for reconstituted suspension
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C protected from light
- Special temperature storage for Vorifast powder for suspension