Emazid L 10 mg+5 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Eskayef pharmaceuticals ltd
Also available as
Emazid l 25 mg tablet

Indications

  • Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases concentrations of active incretin hormones
  • Stimulates release of insulin in a glucose-dependent manner
  • Decreases levels of glucagon
  • Reduces glucagon secretion from pancreatic alpha cells
  • Reduces hepatic glucose output
  • Reduces renal reabsorption of filtered glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily, taken in the morning, with or without food
  • Increased dose: 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m^2
  • Discontinue if eGFR falls below 45 ml/min/1.73 m^2

Interaction

  • Increased urine volume and frequency of voids with diuretics
  • Increased risk for hypoglycemia with Insulin or Insulin secretagogues
  • Efficacy may be reduced when administered with strong P-gp or CYP3A4 inducer
  • Positive urine glucose test
  • Interference with 1,5-anhydroglucitol (1,5-AG) Assay

Contraindications

  • Severe renal impairment, end-stage renal disease, or dialysis
  • History of hypersensitivity reaction to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
  • Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene)
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters of pregnancy
  • Limited data in pregnant women
  • Risks to mother and fetus associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Precaution in conditions such as Pancreatitis, Hypotension, Ketoacidosis, Acute kidney injury and impairment in renal function, Urosepsis and Pyelonephritis, Hypoglycemia, Genital Mycotic Infections, Hypersensitivity
  • Reports of acute pancreatitis and fatal pancreatitis
  • Reports of ketoacidosis, including fatal cases
  • Potential intravascular volume depletion and symptomatic hypotension
  • Increased risk for urinary tract infections
  • Known risk for hypoglycemia with Insulin and Insulin Secretagogues
  • Reports of necrotizing fasciitis of the perineum (Fournier’s gangrene)
  • Increased risk for genital mycotic infections
  • Association with heart failure observed in cardiovascular outcomes trials

Overdose Effects

  • Contact Poison Control Center
  • Employ usual supportive measures
  • Removal of Empagliflozin by hemodialysis not studied
  • Removal of Linagliptin by hemodialysis or peritoneal dialysis unlikely

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30°C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

Related Brands