Emazid L 25 mg+5 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin linagliptin |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise
- Improves glycemic control
- Type 2 diabetes mellitus
Pharmacology
- Inhibits DPP-4 enzyme
- Increases active incretin hormones
- Stimulates insulin release
- Reduces glucagon levels
- Increases insulin biosynthesis
- Reduces glucagon secretion
- Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Increases urinary glucose excretion
Dosage & administration
- 10 mg Empagliflozin and 5 mg Linagliptin once daily
- Taken in the morning
- With or without food
- Increased dose to 25 mg Empagliflozin and 5 mg Linagliptin once daily
- Assess renal function before initiating
- Do not initiate if eGFR is below 45 mL/min/1.73 m^2
- Discontinue if eGFR falls below 45 ml/min/1.73 m^2
Interaction
- Coadministration with diuretics
- Coadministration with Insulin or Insulin secretagogues
- Coadministration with inducers of P-glycoprotein or CYP3A4 Enzymes
- SGLT2 inhibitors increase urinary glucose excretion
- Interferes with 1,5-anhydroglucitol (1,5-AG) Assay
Contraindications
- Severe renal impairment
- End-stage renal disease
- Dialysis
- Hypersensitivity reaction to Linagliptin
- Hypersensitivity reaction to Empagliflozin
Side effects
- Pancreatitis
- Ketoacidosis
- Volume Depletion
- Urosepsis and Pyelonephritis
- Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
- Necrotizing Fasciitis of the Perineum (Fournier's Gangrene)
- Genital Mycotic Infections
- Hypersensitivity Reactions
- Severe and Disabling Arthralgia
- Bullous Pemphigoid
- Heart Failure
Pregnancy & lactation
- Not recommended during second and third trimesters
- Limited available data in pregnant women
- Risks to mother and fetus associated with poorly controlled diabetes in pregnancy
Precautions & warnings
- Pancreatitis
- Hypotension
- Ketoacidosis
- Acute kidney injury and impairment in renal function
- Urosepsis and Pyelonephritis
- Hypoglycemia
- Genital Mycotic Infections
- Hypersensitivity
- Necrotizing Fasciitis of the Perineum (Fournier's Gangrene)
- Heart Failure
Overdose effects
- Contact Poison Control Center
- Usual supportive measures
- Clinical monitoring
- Supportive treatment
Therapeutic class
- Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors
Storage conditions
- Store below 30°C temperature
- Keep away from light and wet place
- Keep out of reach of children