Doparkin 100 mg+10 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levodopa carbidopa fc tablet |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Parkinson's disease treatment
- Parkinson's syndrome treatment
- Relief of parkinsonism symptoms
- Management of tremor
- Management of dysphagia
- Management of sialorrhea
- Postural instability management
- Motor recovery after stroke
Description
- Metabolic precursor of dopamine
- Crosses blood-brain barrier
- Converted to dopamine in the brain
- Dopa decarboxylase (DDC) inhibitor
- Reduces peripheral metabolism of Levodopa
- Increases Levodopa availability to the brain
Dosage & Administration
- Initiation dosage with 100/10 mg tablet
- Titration upward possibility
- Initiation dosage with 250/25 mg tablet
- Maintenance dose adjustment
- Individualized therapy
- Dosage based on Levodopa intake
- Maximum daily dosage limit
- Titration with half to one tablet
Interaction
- Symptomatic postural hypotension risk
- Antihypertensive medicine adjustment
- Adverse reactions with tricyclic antidepressants
- Bioavailability decrease with iron supplements
- Reduced therapeutic effects with dopamine-2 receptor antagonists
- Therapeutic effects reversal by phenytoin and papaverine
- Severe orthostatic hypotension risk with selegiline
Contraindications
- Hypersensitivity to Carbidopa and Levodopa
- Narrow-angle glaucoma
- Risk of malignant melanoma activation
- Suspicious undiagnosed skin lesions
- History of melanoma
Side Effects
- Central neuropharmacologic activity
- Dosage-dependent adverse effects
- Dyskinesias including choreiform, dystonic movements
- Nausea
- Cardiovascular effects
- Gastrointestinal effects
- Haemotologic effects
- Hypersensitivity reactions
- Nervous system effects
- Respiratory effects
- Skin effects
- Urogenital effects
Pregnancy & Lactation
- Unknown effects on human pregnancy
- Visceral and skeletal malformations in animal studies
- Risk assessment in women of childbearing potential
- Unknown excretion in human milk
- Informed decision for nursing mothers
Precautions & Warnings
- Not recommended for medicine-induced extrapyramidal reactions
- Cautious use with pre-existing psychoses
- Administration to patients already taking Levodopa
- Observation for depression and suicidal tendencies
- Cautious administration to patients with cardiovascular or pulmonary disease
- Monitoring of cardiac function in patients with history of myocardial infarction
- Monitoring of intraocular pressure in patients with chronic wide-angle glaucoma
Use in Special Populations
- Use in children: Not recommended for infants and children
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Cool and dry storage
- Protection from light