Olarigen 150 mg (Tablet)
Unit Price: ৳ 833.33 (1 x 120: ৳ 100,000.00)
Strip Price: ৳ 100,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olaparib |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Breast Cancer
- Ovarian Cancer
- Monotherapy
- Metastatic Setting
- Chemotherapy
- Platinum Sensitive Relapsed
- High-Grade Epithelial Ovarian Cancer
- Fallopian Tube Cancer
- Primary Peritoneal Cancer
- Hormone Receptor (HR)-positive Breast Cancer
Pharmacology
- Poly (ADP-ribose) Polymerase (PARP) Enzyme Inhibition
- PARP1 Inhibition
- PARP2 Inhibition
- PARP3 Inhibition
- DNA Transcription
- Cell Cycle Regulation
- DNA Repair
- Tumor Cell Line Growth Inhibition
- Mouse Xenograft Model Tumor Growth Inhibition
- Cytotoxicity
- Antitumor Activity
- BRCA Deficiencies
Dosage & Administration
- Recommended Dose: 400 mg
- Total Daily Dose: 800 mg
- Frequency: Twice Daily
- Administration: Oral
- Dose Reduction for Adverse Reactions
- Dose Modifications for Use with CYP3A Inhibitors
- Dose Modifications for Patients with Renal Impairment
Interaction
- Potentiation with Myelosuppressive Anticancer Agents
- CYP3A Inhibitors Interaction
- CYP3A Inducers Interaction
- Grapefruit Interaction
Contraindications
- Hypersensitivity
Side Effects
- Anemia
- Dermatitis Allergic
- Neutrophil Count Decrease
- Platelet Count Decrease
Pregnancy & Lactation
- Fetal Harm
- Embryo-fetal Toxicity
- Excretion in Human Milk
- Potential Hazard to the Fetus
Precautions & Warnings
- Myelodysplastic Syndrome/Acute Myeloid Leukemia (MDS/AML)
- Hematological Toxicity Monitoring
- Pneumonitis
- Respiratory Symptoms Monitoring
Overdose Effects
- No Specific Treatment
- General Supportive Measures
- Symptomatic Treatment
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Dry Place Storage
- Temperature Limit: Below 30°C
- Light Protection
- Keep Out of Reach of Children