Olarigen 50 mg (Capsule)
Unit Price: ৳ 535.71 (1 x 112: ৳ 60,000.00)
Strip Price: ৳ 60,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olaparib |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Breast Cancer treatment
- Ovarian Cancer maintenance treatment
- HR-positive breast cancer treatment
- Platinum sensitive relapsed cancer treatment
Pharmacology
- PARP inhibitor
- Inhibitor of PARP1, PARP2, and PARP3
- Inhibition of DNA repair
- Tumor growth inhibition
- Selective tumor cell line growth inhibition
- Cytotoxicity induction
Dosage & Administration
- Recommended dose: 400 mg orally twice daily
- Dose continuity until disease progression or unacceptable toxicity
- Dosage modification for adverse reactions
- Dose modification for CYP3A inhibitors
- Dose modification for renal impairment
- Pediatric use not established
Interaction
- Potentiation of myelosuppressive toxicity with anticancer agents
- Increased plasma concentrations with CYP3A inhibitors
- Decreased plasma concentrations with CYP3A inducers
Contraindications
- Hypersensitivity to the drug or any ingredient
Side Effects
- Common serious adverse reaction: anemia
- Other serious adverse reactions reported
- Proportion of patients discontinuing treatment due to adverse events
Pregnancy & Lactation
- Fetal harm potential during pregnancy
- Risk to nursing infants
- Consideration for nursing mothers
Precautions & Warnings
- Myelodysplastic Syndrome/Acute Myeloid Leukemia risk
- Monitoring of complete blood count for cytopenia
- Pneumonitis risk
- Interrupt treatment with respiratory symptoms
- No specific treatment for overdose
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store below 30°C
- Protection from light
- Keep out of reach of children