Xefer 100 mg/2 ml (IV Injection or Infusion)

2 gm vial: ৳ 400.00

Medicine Details

Category Details
Generic Ferric carboxymaltose
Company Ziska pharmaceuticals ltd
Also available as
Xefer 500 mg injection Xefer 1 gm injection

Indications

  • Treatment of iron deficiency anaemia in adult patients with intolerance to oral iron or non-dialysis dependent chronic kidney disease

Therapeutic Class

  • Parenteral Iron Preparations

Description

  • Colloidal iron (III) hydroxide in complex with Carboxymaltose, a Carbohydrate polymer that releases iron

Dosage & Administration

  • Stepwise approach for determination, calculation, and administration of iron dose(s)
  • Calculation based on patient's body weight and haemoglobin level
  • Maximum recommended cumulative dose of 1000 mg of iron per week

Interaction

  • Formal drug interaction studies not performed

Contraindications

  • Hypersensitivity to the active substance or any of its excipients
  • Serious hypersensitivity to other parenteral iron products
  • Anaemia not attributed to iron deficiency
  • Evidence of iron overload or disturbances in the utilisation of iron

Hypertension

  • Transient elevations in systolic blood pressure, sometimes occurring with facial flushing, dizziness, or nausea

Laboratory Test Alterations

  • In the 24 hours following administration of Xefer, laboratory assays may overestimate serum iron and transferrin bound iron

Side Effects

  • Infrequent, mild, and generally do not cause patients to stop treatment
  • Common side effects include nausea, headache, dizziness, and hypertension
  • Uncommon side effects such as hypersensitivity, dysgeusia, tachycardia, and gastrointestinal discomfort
  • Rare side effects like anaphylactoid reactions, loss of consciousness, and respiratory symptoms

Pregnancy & Lactation

  • No adequate and well-controlled trials in pregnant women
  • Animal data suggest potential influence on fetal skeletal development
  • Unlikely risk to breast-fed child based on limited data

Precautions & Warnings

  • Serious hypersensitivity reactions reported
  • Monitoring for signs and symptoms of hypersensitivity during and after administration
  • Transient elevations in systolic blood pressure
  • Laboratory test alterations in the 24 hours following administration

Use in Special Populations

  • Single maximum daily injection dose of 200 mg iron in haemodialysis-dependent chronic kidney disease patients
  • Not recommended in children under 14 years

Overdose Effects

  • Excessive dosages may lead to accumulation of iron in storage sites potentially leading to hemosiderosis
  • Monitoring of iron parameters may assist in recognizing iron accumulation

Storage Conditions

  • Store in a cool (below 30°C) & dry place, away from light
  • Do not freeze
  • Keep out of the reach of children

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