Xefer 1 gm/20 ml (IV Injection or Infusion)

20 ml vial: ৳ 1,300.00

Medicine Details

Category Details
Generic Ferric carboxymaltose
Company Ziska pharmaceuticals ltd
Also available as
Xefer 500 mg injection Xefer 100 mg injection

Indications

  • Treatment of iron deficiency anaemia in adult patients
  • Intolerance to oral iron
  • Non-dialysis dependent chronic kidney disease

Description

  • Colloidal iron (III) hydroxide in complex with Carboxymaltose
  • Carbohydrate polymer that releases iron

Dosage & Administration

  • Stepwise approach for Ferric Carboxymaltose posology
  • Determination of individual iron need
  • Calculation and administration of the iron dose(s)
  • Post-iron repletion assessments

Interaction

  • Formal drug interaction studies not performed with Xefer

Contraindications

  • Hypersensitivity to active substance or its excipients
  • Hypersensitivity to other parenteral iron products
  • Anaemia not attributed to iron deficiency
  • Evidence of iron overload or disturbances in iron utilization

Side Effects

  • Infrequent, mild, generally do not cause treatment discontinuation
  • Common side effects: nausea, headache, dizziness
  • Uncommon side effects: hypersensitivity, dysgeusia, tachycardia
  • Rare side effects: anaphylactoid reactions, loss of consciousness

Pregnancy & Lactation

  • No adequate and well-controlled trials in pregnant women
  • Benefit/risk evaluation required before use during pregnancy
  • Unlikely risk to the breast-fed child

Precautions & Warnings

  • Serious hypersensitivity reactions reported
  • Hypertension: transient elevations in systolic blood pressure
  • Laboratory Test Alterations: overestimate serum iron and transferrin bound iron by also measuring the iron in Xefer

Use in Special Populations

  • Haemodialysis-dependent chronic kidney disease patients: single maximum daily injection dose of 200 mg iron should not be exceeded
  • Not recommended in children under 14 years

Overdose Effects

  • Excessive dosages may lead to accumulation of iron in storage sites

Therapeutic Class

  • Parenteral Iron Preparations

Storage Conditions

  • Store in a cool (below 30°C) & dry place
  • Keep away from light and do not freeze
  • Keep out of the reach of children

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