Carlev CR 200 mg+50 mg (Tablet (Controlled Release))
Unit Price: ৳ 15.00 (2 x 10: ৳ 300.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levodopa carbidopa cr tablet |
| Company | Opsonin pharma ltd |
Indications
- Idiopathic Parkinson's disease
- Reduce off-period in patients previously treated with levodopa/decarboxylase inhibitors
Description
- Metabolic precursor of dopamine
- Crosses the blood-brain barrier
- Conversion to dopamine in the brain
- DDC inhibitor reducing peripheral metabolism of levodopa to dopamine
Dosage
- Initial dosage adjustment
- Titration based on clinical response
- Guideline for conversion from conventional levodopa/carbidopa tablet
Administration
- Initial recommended dose
- Dosage adjustment based on therapeutic response
- Maintenance dosage
- Addition of other antiparkinson medication
- Observation during interruption of therapy
Interaction
- Caution with antihypertensive agents
- Potential interactions with antidepressants, anticholinergics, iron, dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine, selegiline, amino acids, antacids
Contraindications
- Contradiction with sympathomimetic amine
- Non-selective MAO inhibitors contraindicated
- Hypersensitivity to any component
- Narrow-angle glaucoma
- Risk of activating malignant melanoma
Side Effects
- Dyskinesia
- Nausea
- Hallucinations
- Confusion
- Dizziness
- Chorea
- Dry mouth
- Insomnia
- Depression
- Vomiting
- Anorexia
- Chest pain
- Constipation
- Diarrhoea
- Gastro-intestinal pain
- Angioedema
- Urticaria
- Pruritus
- Weight loss
- Neuroleptic malignant syndrome
- Agitation
- Anxiety
- Paraesthesia
- Disorientation
- Fatigue
- Headache
- Extrapyramidal and movement disorders
- Falling
- Gait abnormalities
- Muscle cramps
- On-off phenomenon
- Increased libido
- Psychotic episodes
- Dyspnoea
- Flushing
- Alopecia
- Rash
- Dark sweat
- Blurred vision
- Dark urine
- Cardiac irregularities
- Hypertension
- Phlebitis
- Bitter taste
- Sialorrhoea
- Dysphagia
- Bruxism
- Hiccups
- Gastro-intestinal bleeding
- Flatulence
- Burning sensation of tongue
- Development of duodenal ulcer
- Leucopenia
- Haemolytic and non-haemolytic anaemia
- Thrombocytopenia
- Agranulocytosis
Pregnancy & Lactation
- Insufficient data for evaluation in human pregnancy
- Unknown excretion in human milk
Precautions & Warnings
- Discontinuation of levodopa before therapy
- Occurrence and management of dyskinesias
- Cardiovascular, pulmonary, renal, hepatic or endocrine disease precautions
- Caution in recent myocardial infarction
- Association with somnolence and sudden sleep onset
- Risk of involuntary movements and mental disturbances
- Observation for development of depression or psychoses
- Monitoring for impulse control disorders
Use in Special Populations
- Not recommended for patients below the age of 18
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Cool and dry place
- Protected from light