Zolvo 50 mg (Tablet)
Unit Price: ৳ 50.00 (1 x 10: ৳ 500.00)
Strip Price: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Team pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of invasive aspergillosis
- Treatment of candidemia in nonneutropenic patients
- Treatment of disseminated candidiasis in skin, abdomen, kidney, bladder wall, and wounds
- Treatment of esophageal candidiasis
- Treatment of serious infections caused by Scedosporium apiospermum and Fusarium Species including Fusarium solani
- Treatment for patients intolerant of, or refractory to other therapy
Pharmacology
- Voriconazole is a triazole antifungal medication
- Binds and inhibits ergosterol synthesis
- Inhibits CYP450-dependent 14-alpha sterol demethylase
- Results in depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral administration with specific dosages based on body weight
- Loading dose regimen for different body weight categories
- Maintenance dose regimen for different body weight categories
- Injection administration for specific fungal infections
Interaction
- Requires adjustment of dosage and monitoring for adverse reactions with CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers
- May increase concentrations and activity of drugs that are CYP3A4, CYP2C9 and CYP2C19 substrates
- Increased maintenance oral and intravenous dosage with co-administration of specific drugs
Contraindications
- Known hypersensitivity to Voriconazole or any other components of the drug
- Specific co-administrations leading to risk of serious adverse reactions or loss of efficacy
Side Effects
- Common side effects include abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus
Precautions & Warnings
- Careful assessment of the benefit-risk balance for long term exposure
- Reported cases of squamous cell carcinoma of the skin (SCC) with long-term treatment
Use in Special Populations
- Efficacy in children under 12 years of age is not established
Overdose Effects
- No data available about overdose of Zolvo
Therapeutic Class
- Belongs to the therapeutic class of Other Antifungal preparations
Reconstitution
- Specific instructions for reconstituting the suspension
- Shaking the bottle well before adding water to loosen the powder
- Adding specific amount of boiled and cooled water to the bottle
- Shaking the closed bottle vigorously until the powder is completely mixed with water
- Storage conditions for reconstituted suspension
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C temperature and protected from light
- Additional storage condition for Zolvo powder for suspension