Zolvo 200 mg/5 ml (Powder for Suspension)

40 ml bottle: ৳ 1,000.00

Medicine Details

Category	Details
Generic	Voriconazole
Company	Team pharmaceuticals ltd
Also available as	Zolvo 50 mg tablet Zolvo 200 mg tablet

Indicated for invasive aspergillosis
Treats candidemia and disseminated candidiasis
Esophageal candidiasis treatment
Effective against serious infections caused by Scedosporium apiospermum and Fusarium Species
Suitable for patients intolerant of or refractory to other therapy
Binds and inhibits ergosterol synthesis
Depletes ergosterol in fungal cell membrane
Oral and injection administration
Interaction with CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers
Contraindications due to hypersensitivity to Voriconazole or other components
Common side effects include abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea
Limited studies on pregnancy and lactation
Careful assessment for long term exposure
Efficacy not established for children under 12 years of age
No available data regarding overdose effects
Belongs to therapeutic class of other antifungal preparations
Instructions for reconstitution of suspension
Storage conditions and temperature requirements

Loading dose regimen for patients at or over 40 kg body weight: 400 mg or 10 ml every 12 hours for the first 24 hours
Maintenance dose for patients at or over 40 kg body weight: 200 mg or 5 ml twice daily after the first 24 hours
Loading dose regimen for patients below 40 kg body weight: 200 mg or 5 ml every 12 hours for the first 24 hours
Maintenance dose for patients below 40 kg body weight: 100 mg or 2.5 ml twice daily after the first 24 hours
Loading dose and maintenance dose for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis

Adjust Zolvo dosage with CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers
Monitoring for adverse reactions with increased concentrations and activity of drugs that are CYP3A4, CYP2C9 and CYP2C19 substrates
Increased maintenance oral and intravenous dosage with co-administration of Phenytoin or Efavirenz

Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus
Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John's Wort

Caution for use during pregnancy only if potential benefit justifies potential risk to the fetus

Careful assessment required for long-term exposure (over 180 days)
Reported association with squamous cell carcinoma of the skin (SCC) with long-term treatment

Store in a dry place, below 25°C and protected from light
Specific storage requirement for Zolvo powder for suspension: between 2°C to 8°C