Trivorin 50 mg (Tablet)
Unit Price: ৳ 50.00 (1 x 10: ৳ 500.00)
Strip Price: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Somatec pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of invasive aspergillosis
- Treatment of candidemia and disseminated candidiasis
- Treatment of esophageal candidiasis
- Treatment of serious infections caused by Scedosporium apiospermum and Fusarium Species
- Treatment for patients intolerant of or refractory to other therapy
- Indicated for patients 12 years of age and older
Pharmacology
- Triazole antifungal medication
- Binds and inhibits ergosterol synthesis
- Inhibits CYP450-dependent 14-alpha sterol demethylase
- Results in depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral tablet and powder for suspension
- Taken at least one hour before or after a meal
- Different loading and maintenance doses based on body weight
- Injection dosage for different infections
Interaction
- Requires adjustment of dosage and monitoring for adverse reactions with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- May increase concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
- Increased maintenance dosage with co-administration of Phenytoin or Efavirenz
Contraindications
- Known hypersensitivity to Voriconazole or components of the drug
- Co-administration with specific drugs due to risk of serious adverse reactions or loss of efficacy
Side Effects
- Abdominal pain
- Anemia
- Blurred vision
- Headache
- Chest pain
- Nausea
- Diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if potential benefit justifies potential risk to the fetus
Precautions & Warnings
- Long-term exposure requires careful assessment of benefit-risk balance
- Reported association with squamous cell carcinoma of the skin with long-term treatment
Use in Special Populations
- Efficacy not established for children under 12 years of age
Overdose Effects
- No data available
Therapeutic Class
- Other Antifungal preparations
Reconstitution
- Instructions for shaking and adding water to the powder for suspension
- Storage instructions for reconstituted suspension
Storage Conditions
- Keep out of reach of children
- Store in dry place below 25°C and protected from light
- Different storage temperature for Trivorin powder for suspension