Clorel-A 75 mg+75 mg (Tablet)

Unit Price: ৳ 12.04 (3 x 10: ৳ 361.20)
Strip Price: ৳ 120.40

Medicine Details

Category Details
Generic Clopidogrel aspirin
Company Aci limited

Title

  • Clorel-A Tablet

Categories

  • Medicine
  • Healthcare
  • Pharmaceutical

Description

  • A tablet indicated for reducing the rate of myocardial infarction (MI) and stroke in patients with acute coronary syndrome (ACS), recent MI, recent stroke, or established peripheral arterial disease
  • Contains the prodrug Clopidogrel which inhibits platelet activation and aggregation, and aspirin which inhibits platelet aggregation by irreversible inhibition of platelet cyclooxygenase
  • Recommended dosage is 75 mg once daily, with or without food
  • Combination contraindicated in conditions like hypersensitivity to the drug substance, active pathological bleeding such as peptic ulcer or intracranial hemorrhage
  • Should be used with caution in pregnant women and during breastfeeding
  • May prolong bleeding time and has been associated with TTP and Reye's syndrome
  • Not recommended for children under 12 years

Color Options

  • White

Dimensions

  • Standard tablet size

Pharmacological Action

  • Inhibits platelet activation and aggregation through irreversible binding to the P2Y12 class of ADP receptors on platelets
  • Inhibits platelet aggregation by irreversible inhibition of platelet cyclooxygenase and inhibiting the generation of thromboxane A2

Mode of Action

  • Dose-dependent inhibition of platelet aggregation observed at 2 hours after single oral doses
  • Repeated doses of 75 mg per day inhibit ADP-induced platelet aggregation on the first day
  • Inhibition reaches steady state between Day 3 and Day 7
  • Plasma concentrations of the parent compound are very low and generally below the quantification limit beyond 2 hours after dosing
  • Main circulating metabolite is the carboxylic acid derivative, representing about 85% of the circulating drug-related compounds in plasma
  • Approximately 50% excreted in the urine and approximately 46% in the faeces in the 5 days after dosing
  • Elimination half-life of the main circulating metabolite is 8 hours after single and repeated administration
  • Clopidogrel is rapidly absorbed after oral administration of repeated doses
  • Peak plasma levels of the main circulating metabolite occur approximately 1 hour after dosing
  • Main circulating metabolite binds reversibly in vitro to human plasma proteins (94%)

Dosage and Administration

  • Recommended dose is 75 mg once daily with or without food
  • No dosage adjustment necessary for elderly patients or patients with renal impairment
  • For patients with acute coronary syndrome, Clopidogrel should be initiated with a single 300 mg loading dose and continued at 75 mg once daily
  • Aspirin (75 mg-325 mg once daily) should be initiated and continued in combination with Clopidogrel
  • Most patients with acute coronary syndrome also received heparin acutely

Specific Drug Interactions

  • Aspirin does not modify the Clopidogrel-mediated inhibition of ADP-induced platelet aggregation
  • Clopidogrel potentiates the effect of aspirin on collagen-induced platelet aggregation
  • Clopidogrel does not alter the effect of heparin on coagulation
  • Concomitant administration of Clopidogrel is associated with increased occult gastrointestinal blood loss when co-administered with NSAIDs

Contraindications

  • Hypersensitivity to the drug substance or any component of the product
  • Active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side Effects

  • Generally well tolerated

Pregnancy and Lactation

  • No adequate and well-controlled studies in pregnant women
  • Use during first and second trimesters of pregnancy only if clearly needed
  • Contraindicated during the third trimester of pregnancy
  • Unknown whether Clopidogrel is excreted in human breast milk, aspirin is known to be excreted in human milk
  • Drug should be discontinued during breastfeeding

Precautions and Warnings

  • May prolong bleeding time
  • TTP has been reported rarely following use of Clorel-A
  • Reye's syndrome may develop in individuals who have chicken pox, influenza or flu symptoms
  • Hypersensitivity, including rash, angioedema, or hematologic reaction, has been reported in patients receiving Clorel-A

Use in Special Populations

  • Not recommended for children, particularly those under 12 years

Overdose Effects

  • Clopidogrel overdose may lead to bleeding complications
  • Moderate aspirin intoxication symptoms can be treated by inducing vomiting followed by gastric lavage if needed
  • Severe aspirin intoxication symptoms can be treated with hemodialysis and other symptomatic treatment

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep in a cool & dry place (below 30°C), protected from light & moisture
  • Keep out of the reach of children

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