Cazar 20 mg (Capsule)

Unit Price: ৳ 1,740.00 (1 x 21: ৳ 36,540.00)
Strip Price: ৳ 36,540.00

Medicine Details

Category Details
Generic Cabozantinib
Company Jenphar bangladesh ltd

Indications

  • Treatment of advanced renal cell carcinoma (RCC)
  • Treatment of hepatocellular carcinoma (HCC) after Sorafenib treatment

Pharmacology

  • Inhibition of tyrosine kinase activity of MET, VEGFR-1, -2 and -3, AXL, RET, ROS1, TYRO3, MER, KIT, TRKB, FLT-3, TIE-2
  • Receptor tyrosine kinases involved in cellular function, oncogenesis, metastasis, tumor angiogenesis, drug resistance
  • Absorption within 3-4 hours post-dose
  • Distribution with high protein binding in human plasma
  • Predicted terminal half-life of approximately 99 hours
  • Metabolism as a substrate of CYP3A4 in vitro
  • Excretion of approximately 54% in feces and 27% in urine

Dosage & Administration

  • Recommended dosage of 60 mg once daily without food for renal cell carcinoma
  • Recommended dosage of 60 mg once daily without food for hepatocellular carcinoma
  • Dosage adjustment for patients with hepatic impairment and those taking CYP450 inhibitors/inducers
  • Precautions for administration near scheduled surgery, capsule substitution, food intake, and missed doses

Interaction

  • Increased exposure and risk of adverse reactions with strong CYP3A4 inhibitors
  • Decreased exposure and reduced efficacy with strong CYP3A4 inducers
  • Avoidance of coadministration with grapefruit or grapefruit juice, and St. John's Wort

Contraindications

  • Contraindicated in patients with known hypersensitivity to Cabozantinib or any other components

Side Effects

  • Hemorrhage
  • Perforations and Fistulas
  • Thrombotic Events
  • Hypertension and Hypertensive Crisis
  • Diarrhea
  • Palmar-plantar Erythrodysesthesia
  • Proteinuria
  • Osteonecrosis of the Jaw
  • Wound Complications
  • Reversible Posterior Leukoencephalopathy Syndrome

Pregnancy & Lactation

  • Potential fetal harm during pregnancy
  • Advisement against breastfeeding during treatment and for 4 months after the final dose
  • Requirement for effective contraception in females of reproductive potential
  • Potential impairment of fertility in females and males based on animal studies

Precautions & Warnings

  • Discontinuation for severe hemorrhage, recent history of hemorrhage, and signs of fistulas and perforations
  • Risk of thrombotic events and need for regular blood pressure monitoring
  • Management of diarrhea, palmar-plantar erythrodysesthesia, proteinuria, osteonecrosis of the jaw, wound complications, and reversible posterior leukoencephalopathy syndrome
  • Consideration of embryo-fetal toxicity and associated risks

Overdose Effects

  • Reported case involving memory impairment, mental status changes, cognitive disturbance, weight loss, and increase in BUN

Therapeutic Class

  • Tyrosine Kinase Inhibitor

Storage Conditions

  • Storage below 30°C in a cool, dry place away from sunlight
  • Storage out of reach of children

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