Cabanib 20 mg (Capsule)

Unit Price: ৳ 120.00 (3 x 10: ৳ 3,600.00)
Strip Price: ৳ 1,200.00

Medicine Details

Category Details
Generic Cabozantinib
Company Drug international ltd
Also available as
Cabanib 60 mg capsule

Indications

  • Renal Cell Carcinoma
  • Hepatocellular Carcinoma

Pharmacology

  • Inhibition of MET kinase activity
  • Inhibition of VEGFR kinase activity
  • Inhibition of AXL kinase activity
  • Inhibition of RET kinase activity
  • Inhibition of KIT kinase activity
  • Highly protein-bound in human plasma

Absorption

  • Median time to peak concentration: 3-4 hours
  • 19% increase in Cmax observed following a 140 mg dose
  • Less than 10% difference in AUC observed

Distribution

  • Oral volume of distribution: 319 L

Elimination

  • Terminal half-life: approximately 99 hours
  • Clearance at steady state: 2.2 L/hr

Metabolism

  • Substrate of CYP3A4 in vitro

Excretion

  • 81% of total administered radioactivity recovered within 48-day period
  • 54% recovered in feces, 27% in urine

Dosage & Administration

  • Recommended dosage for Renal Cell Carcinoma: 60 mg once daily without food
  • Recommended dosage for Hepatocellular Carcinoma: 60 mg once daily without food
  • Stop treatment at least 28 days prior to scheduled surgery
  • Do not substitute with capsules
  • Swallow whole, do not crush
  • Do not take missed dose within 12 hours of next dose
  • Pediatric use not established

Interaction

  • Avoid coadministration with strong CYP3A4 inhibitors
  • Avoid grapefruit or grapefruit juice
  • Avoid coadministration with strong CYP3A4 inducers
  • Avoid St. John's Wort

Contraindications

  • Known hypersensitivity to Cabozantinib or any other components

Side Effects

  • Hemorrhage
  • Perforations and Fistulas
  • Thrombotic Events
  • Hypertension and Hypertensive Crisis
  • Diarrhea
  • Palmar-plantar Erythrodysesthesia
  • Proteinuria
  • Osteonecrosis of the Jaw
  • Wound Complications
  • Reversible Posterior Leukoencephalopathy Syndrome

Pregnancy & Lactation

  • Potential fetal harm
  • No information in human milk
  • Advice not to breastfeed during treatment
  • Use effective contraception
  • Potential impairment of fertility in females and males

Precautions & Warnings

  • Severe hemorrhages
  • Fistulas and perforations
  • Increased risk of thrombotic events
  • Hypertension and hypertensive crisis
  • Diarrhea management
  • Palmar-plantar erythrodysesthesia management
  • Proteinuria monitoring
  • Osteonecrosis of the jaw monitoring
  • Wound complications management
  • Reversible Posterior Leukoencephalopathy Syndrome evaluation
  • Embryo-Fetal toxicity

Overdose Effects

  • Case of overdosage reported
  • Patient suffered memory impairment, mental status changes, cognitive disturbance, weight loss, increase in BUN

Therapeutic Class

  • Tyrosine Kinase Inhibitor

Storage Conditions

  • Store below 30°C
  • Keep in a cool and dry place
  • Keep away from sunlight
  • Keep out of reach of children

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