Caboxen 80 mg (Capsule)
Unit Price: ৳ 1,100.00 (1 x 30: ৳ 33,000.00)
Strip Price: ৳ 33,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cabozantinib |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of advanced renal cell carcinoma (RCC)
- Treatment of hepatocellular carcinoma (HCC)
Pharmacology
- Inhibits tyrosine kinase activity of various receptors
- Median time to peak concentration is 3-4 hours post-dose
- Highly protein-bound in plasma
- Predicted terminal half-life is approximately 99 hours
Dosage & Administration
- Recommended dosage is 60 mg once daily without food
- Dosage for renal cell carcinoma
- Dosage for hepatocellular carcinoma
- Specific instructions on administration and precautions
Interaction
- Avoid coadministration with strong CYP3A4 inhibitors
- Avoid grapefruit or grapefruit juice
- Avoid coadministration with strong CYP3A4 inducers
- Avoid St. John's Wort
Contraindications
- Contraindicated in patients with known hypersensitivity
Side Effects
- Hemorrhage
- Perforations and Fistulas
- Thrombotic Events
- Hypertension and Hypertensive Crisis
- Diarrhea
- Palmar-plantar Erythrodysesthesia
- Proteinuria
- Osteonecrosis of the Jaw
- Wound Complications
- Reversible Posterior Leukoencephalopathy Syndrome
Pregnancy & Lactation
- Can cause fetal harm in pregnancy
- No information regarding presence in human milk
- Advisory on contraception and infertility potential
Precautions & Warnings
- Severe and fatal hemorrhages
- Fistulas and Gastrointestinal perforations
- Increased risk of thrombotic events
- Hypertension and hypertensive crisis
- Diarrhea and palmar-plantar erythrodysesthesia
- Proteinuria and osteonecrosis of the jaw
- Wound complications and reversible posterior leukoencephalopathy syndrome
Overdose Effects
- Reported case of overdosage with associated symptoms
Therapeutic Class
- Tyrosine Kinase Inhibitor
Storage Conditions
- Store below 30°C in a cool and dry place, away from sunlight