Ovaxa 100 mg (Capsule)
Unit Price: ৳ 1,000.00 (1 x 14: ৳ 14,000.00)
Strip Price: ৳ 14,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Niraparib |
| Company | Jenphar bangladesh ltd |
Indications
- Maintenance treatment for ovarian cancer
- Platinum-based chemotherapy response
Pharmacology
- PARP inhibitor
- DNA repair role
- Cytotoxicity induction
- Apoptosis induction
- DNA damage
- Inhibition of PARP enzymatic activity
- Increased formation of PARP-DNA complexes
- BRCA1/2 deficiencies sensitivity
- Tumor growth inhibition
- Metabolism by carboxylesterases and glucuronidation
- Excretion in urine and feces
Dosage & Administration
- 300 mg oral monotherapy
- Once daily
- Swallow whole with water
- Can be taken with or without food
- Bedtime administration for nausea management
- Start treatment within 8 weeks after platinum-containing regimen
- Continue until disease progression or unacceptable toxicity
Interaction
- Inhibition of CYPs
- Potential CYP3A4 inhibition at intestinal level
- Induction of CYP1A2 at high concentrations
- Caution with CYP3A4/CYP1A2-dependent active substances
Contraindications
- Hypersensitivity to active substance or excipients
- Breastfeeding
Side Effects
- Nausea
- Thrombocytopenia
- Fatigue/asthenia
- Anemia
- Constipation
- Vomiting
- Abdominal pain
- Neutropenia
- Insomnia
- Headache
- Decreased appetite
- Nasopharyngitis
- Diarrhea
- Dyspnea
- Hypertension
- Dyspepsia
- Back pain
- Dizziness
- Cough
- Urinary tract infection
- Arthralgia
- Palpitations
- Dysgeusia
- Serious adverse reactions: thrombocytopenia and anemia
Pregnancy & Lactation
- Contraception for women of childbearing potential
- Pregnancy test prior to treatment
- Effective contraception during and 1 month after treatment
- Avoid use during pregnancy and breastfeeding
- Potential embryonic or fetal harm
- No data on excretion in human milk
- Unknown effects on fertility
Precautions & Warnings
- Myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) risk
- Hypertension risk
- Pre-existing hypertension control
- Monthly blood pressure monitoring
- Pregnancy and contraception precautions
- Lactose content caution
- Tartrazine (E102) allergic reaction risk
Use in Special Populations
- No dose adjustment for elderly patients
- Limited data for patients aged 75 or over
- Unknown safety and efficacy in children and adolescents
- No established data for severe renal impairment or end-stage renal disease
- Caution for severe hepatic impairment
Overdose Effects
- No specific treatment
- General supportive measures
- Symptomatic treatment
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Cool and dry storage below 30°C
- Avoid exposure to temperatures above 40°C or 104°F
- Keep out of reach and sight of children