Telabee 25 mg (Tablet)
Unit Price: ৳ 150.00 (1 x 10: ৳ 1,500.00)
Strip Price: ৳ 1,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tenofovir alafenamide |
| Company | Jenphar bangladesh ltd |
Indications
- Treatment of chronic hepatitis B virus infection in adults with compensated liver disease
Pharmacology
- Tenofovir alafenamide is a phosphonamidate prodrug of tenofovir
- Tenofovir alafenamide enters primary hepatocytes by passive diffusion
- Converted to tenofovir through hydrolysis primarily by carboxylesterase 1 (CES1)
- Intracellular tenofovir inhibits HBV replication through incorporation into viral DNA
- Weak inhibitor of mammalian DNA polymerases
Dosage & Administration
- Testing for HIV-1 infection prior to initiation
- Recommended dosage of Tenofovir alafenamide is 25 mg once daily with food
- No dosage adjustment in patients with estimated creatinine clearance greater than or equal to 15 ml per minute
Interaction
- Telabee is a substrate of P-glycoprotein (P-gp) and BCRP
- Drugs that strongly affect P-gp and BCRP activity may lead to changes in Telabee absorption
- Coadministration with drugs that inhibit P-gp and BCRP may increase the absorption & plasma concentration
Side Effects
- Common side effects include headache, stomach pain, tiredness, cough, nausea, back pain
Pregnancy & Lactation
- Prevalence of birth defects in live births following exposure to TAF-containing regimens
- Effect of Tenofovir alafenamide on breastfed infants should be considered
Precautions & Warnings
- Discontinuation of treatment may result in severe acute exacerbations of hepatitis B
- Telabee alone is not recommended for the treatment of HIV-1 infection
- Postmarketing cases of renal impairment have been reported with TAF-containing products
Overdose Effects
- Monitor patient for evidence of toxicity
- Treatment of overdosage with Telabee consists of general supportive measures
- Telabee is efficiently removed by hemodialysis
Therapeutic Class
- Hepatic viral infections (Hepatitis B)
Storage Conditions
- Store below 30°C
- Keep it in its original container
- Protect from light
- Keep out of children’s reach