Formet XR 750 mg (Tablet (Extended Release))
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Biopharma limited |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in overweight patients
- Monotherapy or combination therapy for adults and children
- Reducing diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
Biguanide type oral antihyperglycemic drug for type 2 diabetes management
Dosage & Administration
- Metformin immediate release tablet:
- Usual starting dose for adults: 500 mg twice a day or 850 mg once a day
- Maximum daily dose for adults: 2550 mg
- Starting dose for children: 500 mg twice a day
- Maximum daily dose for children: 2000 mg
- Metformin extended release tablet:
- Usual starting dose for adults: 500 mg once daily
- Maximum daily dose for adults: 2000 mg once daily or 1000 mg twice daily
- Not studied in children
- Renal impaired patient: Avoid use in patients with eGFR below 30 mL/min/1.73 m^2
Interaction
- Potential interaction with Furosemide and Nifedipine
- Effect on cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Vitamin B12 absorption reduction
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Pregnancy: Not recommended, insulin preferred for maintaining normal blood glucose levels
- Breastfeeding: Excreted into human breast milk, limited data available
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia when used with insulin
- Regular monitoring of renal function
- Therapy cessation before certain clinical investigations and surgery
- Caution in conditions causing dehydration or serious infections
- Annual estimation of Vitamin B-12 levels
- Blood glucose monitoring during combined therapy with a sulphonylurea
- Reduced renal clearance during cimetidine therapy
- Possible interaction with anticoagulants
Use in Special Populations
- Elderly: Dosage adjustment based on renal function
- Pediatric population: Diagnosis confirmation before initiation, no effect on growth and puberty detected
- Children aged between 10 and 12 years: Caution recommended
- Renal function: Creatinine clearance determination before and during treatment, contraindicated in patients with GFR < 30 ml/min
Overdose Effects
Hypoglycemia not seen with usual doses, lactic acidosis is a medical emergency
Therapeutic Class
Biguanides
Storage Conditions
Keep below 30°C, protected from light & moisture, out of the reach of children