Hexirest 2 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders caused by CNS drugs
Description
- Exerts direct inhibitory effect on the parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds higher affinity to M1 subtype
- Higher affinity for central muscarinic receptors
Dosage & Administration
- Should be individualized
- Initial dose should be low and increased gradually
- Total daily dose depends on patient's reaction
Interactions
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of CNS depressants
Contraindications
- Contra-indicated in patients with hypersensitivity to Trihexyphenidyl
- Contra-indicated in patients with narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Mild nausea or nervousness
- Suppurative parotitis
- Skin rashes
- Constipation
- Exacerbation of parkinsonism with abrupt treatment withdrawal
Pregnancy & Lactation
- Not enough data on use during pregnancy
- Caution advised when administered to a nursing woman
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Monitoring of intraocular pressures
- Caution in hot weather and with concomitant use with other atropine-like drugs
Overdose Effects
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs such as delirium, anxiety, hallucinations
- Treatment involves symptomatic and supportive therapy
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Store in a dry place
- Protect from light